Escin attenuates oxidative damage, apoptosis and lipid peroxidation in a model of cyclophosphamide-induced liver damage

Basit Öğe Kaydı
dc.authoridCENGIZ, Mustafa/0000-0002-6925-8371
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorKutlu, Hatice Mehtap
dc.contributor.authorPeker Cengiz, Betul
dc.contributor.authorAyhanci, Adnan
dc.date.accessioned2024-12-24T19:28:03Z
dc.date.available2024-12-24T19:28:03Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractTo investigate the effects of escin (ES) on acute damage induced by alkylating agent, experimental rats were injected with cyclophosphamide (CPM) to cause liver damage. The animals were divided into four groups: Control Group, CPM (200 mg/kg), ES (10 mg/kg), CPM, and ES Groups. Immunohistopathological, hepatic histopathological, and biochemical changes were analyzed. The activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), malondyaldehyde (MDA), glutathion (GSH), total oxidant status (TOS) and total antioxidant status (TAS) in serum were all determined. Serum and immunohistopathology analysis revealed that MDA, ALT, AST, LDH, TOC and OSI, caspase-3 and Bax levels had increased while GSH, TAC, Bcl- 2 and OSI levels decreased in CPM Group when compared to Control Group. These findings appear to account for the severe damage detected. In the CPM + ES treated group, positive improvements were found in biochemical parameters as well as in cell-death and tissue-related damage parameters.The results show that ES considerably protects the rat liver against CPM-induced hepatotoxicity thanks to because of its anti-oxidant and anti-apoptotic properties.
dc.identifier.doi10.1080/01480545.2020.1810262
dc.identifier.endpage1187
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue3
dc.identifier.pmid32838567
dc.identifier.scopus2-s2.0-85089728194
dc.identifier.scopusqualityQ1
dc.identifier.startpage1180
dc.identifier.urihttps://doi.org/10.1080/01480545.2020.1810262
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6904
dc.identifier.volume45
dc.identifier.wosWOS:000562226300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofDrug and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectEscin
dc.subjectcyclophosphamide
dc.subjectcell death
dc.subjectliver damage
dc.subjectanti-apoptotic
dc.titleEscin attenuates oxidative damage, apoptosis and lipid peroxidation in a model of cyclophosphamide-induced liver damage
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu