Induction of Heat Shock Proteins 27, 60, 70, and 90 in the Cerebellum of Rats After Hyperthermia During Postnatal Development

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dc.authoridBAYRAKTAROGLU, ALEV GUROL/0000-0001-9248-8370
dc.contributor.authorKandil, Banu
dc.contributor.authorBayraktaroglu, Alev Gurol
dc.date.accessioned2024-12-24T19:28:30Z
dc.date.available2024-12-24T19:28:30Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractHeat shock proteins (HSPs) are induced in response to stressful stimuli and play an important role in cell repair and protection. This study, using immunohistochemistry, aimed to determine whether HSPs are induced in the cerebellum of rats subjected to hyperthermia during postnatal development (PND). The results showed that unlike HSP27 and HSP70, HSP60 and HSP90 were constitutively expressed in the cerebellum of rats. However, hyperthermia induced HSP27 in the white matter (WM) and HSP70 in the Bergmann glial cells, the internal granule layer (IGL), and the WM. In the WM, HSP27 induction was only observed on days PND20, PND25, and PND30, and HSP27 expression was higher on day PND30 compared with days PND20 and PND25 (p < 0.001). In the Bergmann glial cells, HSP70 induction was only observed on days PND5, PND10, and PND20, and HSP70 expression was greater on days PND5 and PND10 compared with day PND20 (p < 0.001). In the IGL and the WM, HSP70 expression was higher on days PND20, PND25, and PND30 compared with days PND5 and PND10 (p < 0.001). These findings indicate that unlike HSP60 and HSP90, HSP27 and HSP70 have different expression patterns in the cerebellum of rats after hyperthermia during PND.
dc.description.sponsorshipIn writing our article, no financial support was received from any institution or organization.
dc.identifier.doi10.1093/mam/ozae075
dc.identifier.endpage952
dc.identifier.issn1431-9276
dc.identifier.issn1435-8115
dc.identifier.issue5
dc.identifier.pmid39189886
dc.identifier.scopus2-s2.0-85208514024
dc.identifier.scopusqualityQ4
dc.identifier.startpage944
dc.identifier.urihttps://doi.org/10.1093/mam/ozae075
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7090
dc.identifier.volume30
dc.identifier.wosWOS:001299200300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Press
dc.relation.ispartofMicroscopy and Microanalysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectcerebellum
dc.subjectheat shock protein
dc.subjecthyperthermia
dc.subjectpostnatal development
dc.subjectrat
dc.titleInduction of Heat Shock Proteins 27, 60, 70, and 90 in the Cerebellum of Rats After Hyperthermia During Postnatal Development
dc.typeReview Article

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