Association of viral load with age, gender, disease severity, and death in severe acute respiratory syndrome coronavirus 2 variants

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dc.authoridOzudogru, Osman/0000-0003-1212-2251
dc.authoridAcer, Omer/0000-0002-5314-0475
dc.contributor.authorAcer, Omer
dc.contributor.authorGenc Bahce, Yasemin
dc.contributor.authorOzudogru, Osman
dc.date.accessioned2024-12-24T19:24:12Z
dc.date.available2024-12-24T19:24:12Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractIn this study, the relationship between viral load, demographic characteristics, and disease information in 1007 (48.5%) patients with Delta variant (B.1.617.2), and 1070 (51.5%) patients with Alpha variant (B1.1.7) were investigated. We found that there was a significant difference in viral load between patients who died from the Alpha variant and those who were discharged (p < 0.05). Nevertheless, no significant difference was observed in patients with the Delta variant. The viral load in patients who died from the Alpha variant was significantly higher than those who were discharged (p < 0.05). The viral load was found to be higher in females in patients with the Delta variant, whereas it was very close in males and females in patients with the Alpha variant (p > 0.05). No significant difference was detected between the cycle threshold values (Ct) and disease severity. In terms of the mean Ct values, statistical differences were observed in patients with Delta and Alpha variants. The Alpha variant was found to have a higher viral load than the Delta variant. Furthermore, the Delta variant was found to be higher in the 40-year-old and under-age group than the Alpha variant, whereas the Alpha variant was higher in the groups over 40 years old. Although the rate of moderate and severe patients in the Alpha variant was found to be higher, the rate of mild survivors was found to be higher in the Delta variant. In conclusion, the increase in vaccination before the appearance of the Delta variant in our region may have influenced the viral load and clinical status of the patients.
dc.identifier.doi10.1002/jmv.27677
dc.identifier.endpage3069
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.issue7
dc.identifier.pmid35212012
dc.identifier.scopus2-s2.0-85125941684
dc.identifier.scopusqualityQ1
dc.identifier.startpage3063
dc.identifier.urihttps://doi.org/10.1002/jmv.27677
dc.identifier.urihttps://hdl.handle.net/20.500.12604/5892
dc.identifier.volume94
dc.identifier.wosWOS:000766228800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Medical Virology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectalpha variant
dc.subjectCt value
dc.subjectdelta variant
dc.subjectSARS-CoV-2
dc.subjectviral loads
dc.titleAssociation of viral load with age, gender, disease severity, and death in severe acute respiratory syndrome coronavirus 2 variants
dc.typeArticle

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