Ranolazine improved left ventricular diastolic functions and ventricular repolarization indexes in patients with coronary slow flow

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dc.authoridOzmen, Emre/0000-0003-0673-7938
dc.contributor.authorOksen, Dogac
dc.contributor.authorAslan, Muzaffer
dc.contributor.authorOzmen, Emre
dc.contributor.authorYavuz, Yunus Emre
dc.date.accessioned2024-12-24T19:31:05Z
dc.date.available2024-12-24T19:31:05Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractIntroductionCoronary slow flow (CSF) is a condition commonly encountered during angiography. Recent studies have shown the adverse effects of CSF on left ventricular diastolic functions. CSF reportedly increases the novel ventricular repolarization parameters. Ranolazine is a preparation with a prominent anti-anginal activity that has positive effects on anti-arrhythmic and diastolic parameters. In this context, this study was carried out to investigate the effects of ranolazine on left ventricular diastolic functions and repolarization in patients with CSF.Material and methodsForty-six patients with CSF and 29 control subjects were included in the patient and control groups, respectively. Both groups received ranolazine for one month and were evaluated using 12-lead electrocardiography, conventional echocardiography, and tissue Doppler imaging at the baseline and after one month of ranolazine treatment.ResultsCorrected P, QT dispersion, and Tp-e interval values were significantly higher in the patient group than in the control group. There was a significant decrease in isovolumic relaxation time (IVRT) and deceleration time (DT) values after the ranolazine treatment compared to the baseline values in the patient group but not the control group. A significant increase was observed in the mean E and A velocities and the mean E/A ratio after the ranolazine treatment compared to the baseline values in the patient group. Additionally, there was a significant difference between the Tp-e interval and corrected P dispersion values measured after the ranolazine treatment compared to the baseline values in the patient group but not in the control group.ConclusionThis study's findings demonstrated that ranolazine positively affected impaired diastolic functions and repolarization parameters, particularly in patients with CSF.
dc.identifier.doi10.3389/fcvm.2023.1207580
dc.identifier.issn2297-055X
dc.identifier.pmid37671136
dc.identifier.scopus2-s2.0-85169686049
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3389/fcvm.2023.1207580
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7809
dc.identifier.volume10
dc.identifier.wosWOS:001057918200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers in Cardiovascular Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectranolazine
dc.subjectrepolarization indexes
dc.subjectcoronary slow flow
dc.subjecttissue doppler imaging
dc.subjectcoronary circulation
dc.subjectelectrocardiography
dc.titleRanolazine improved left ventricular diastolic functions and ventricular repolarization indexes in patients with coronary slow flow
dc.typeArticle

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