Synthesis of 2-substituted 8-propargyloxyquinoline derivatives and determination of their antioxidant, antibacterial, and DNA binding activities

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dc.authoridGumus, Aysegul/0000-0002-1613-7074
dc.authoridGumus, Selcuk/0000-0002-8628-8943
dc.authoridOkumus, Veysi/0000-0002-5505-2700
dc.contributor.authorGumus, Aysegul
dc.contributor.authorOkumus, Veysi
dc.contributor.authorGumus, Selcuk
dc.date.accessioned2024-12-24T19:33:57Z
dc.date.available2024-12-24T19:33:57Z
dc.date.issued2018
dc.departmentSiirt Üniversitesi
dc.description.abstract2-Substituted 8-propargyloxyquinoline derivatives have been synthesized from 2-substituted-8-hydroxyquinolines by O-propargylation method (30%-98% yields). The newly synthesized compounds were tested for in vitro antioxidant activities such as DPPH radical scavenging, ferrous chelating, and reducing power activities. The maximum radical scavenging (46.5%) and reducing power activities were obtained from 1 and maximum ferrous chelating effect was obtained from 6 (72.1%) at the concentration of 500 mu g/mL. To indicate DNA binding activity of the complexes calf thymus DNA was used. The compounds were also evaluated for their antimicrobial activity against three gram-positive and three gram-negative bacteria. Compounds 3 and 5 exhibited antibacterial activity against all tested gram-positive bacteria.
dc.identifier.doi10.3906/kim-1805-77
dc.identifier.endpage1369
dc.identifier.issn1300-0527
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85054925234
dc.identifier.scopusqualityQ3
dc.identifier.startpage1358
dc.identifier.trdizinid381746
dc.identifier.urihttps://doi.org/10.3906/kim-1805-77
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/381746
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8347
dc.identifier.volume42
dc.identifier.wosWOS:000451313100014
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectQuinoline
dc.subjectpropargyloxyquinoline
dc.subjectantioxidant
dc.subjectantibacterial
dc.subjectDNA binding activity
dc.titleSynthesis of 2-substituted 8-propargyloxyquinoline derivatives and determination of their antioxidant, antibacterial, and DNA binding activities
dc.typeArticle

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