The Protective Effects of Silymarin on Thioacetamide-Induced Liver Damage: Measurement of miR-122, miR-192, and miR-194 Levels

Basit Öğe Kaydı
dc.authoridSahinturk, Varol/0000-0003-2317-3644
dc.authoridCENGIZ, Mustafa/0000-0002-6925-8371
dc.authoridTEKSOY, OZGUN/0000-0002-9402-3734
dc.contributor.authorTeksoy, Ozgun
dc.contributor.authorSahinturk, Varol
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorInal, Behcet
dc.contributor.authorAyhanci, Adnan
dc.date.accessioned2024-12-24T19:24:54Z
dc.date.available2024-12-24T19:24:54Z
dc.date.issued2020
dc.departmentSiirt Üniversitesi
dc.description.abstractThis study aims to investigate the protective effects of silymarin (Sm) in thioacetamide (TAA)-related liver damage. What makes this study special is that it attempts to determine the expression of changes in the liver at the level of gene expression. Routine liver damage markers were compared with changes in the levels of microRNA (miRNA) known as new biomarkers. With this in mind, we divided the rats into four groups including control, TAA, Sm + TAA (50 + 50 mg/kg), and Sm + TAA (100 + 50 mg/kg). Blood and tissue samples belonging to the rats were collected in consideration of morphological, immunohistochemistry, miRNAs levels, and biochemical evaluations. Our study results showed that miR-122, miR-192, and miR-194 levels had decreased in the experimental groups given TAA, whereas miR-122, miR-192, and miR-194 levels had increased in the doses of Sm + TAA-given group. Therefore, Sm treatment undertaken before exposure to the toxin successfully altered its effects upon the study animals.
dc.identifier.doi10.1007/s12010-019-03177-w
dc.identifier.endpage539
dc.identifier.issn0273-2289
dc.identifier.issn1559-0291
dc.identifier.issue2
dc.identifier.pmid31811641
dc.identifier.scopus2-s2.0-85076228024
dc.identifier.scopusqualityQ2
dc.identifier.startpage528
dc.identifier.urihttps://doi.org/10.1007/s12010-019-03177-w
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6186
dc.identifier.volume191
dc.identifier.wosWOS:000541559900005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofApplied Biochemistry and Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectThioacetamide
dc.subjectSilymarin
dc.subjectmiRNA
dc.subjectImmunohistochemistry
dc.subjectRat
dc.titleThe Protective Effects of Silymarin on Thioacetamide-Induced Liver Damage: Measurement of miR-122, miR-192, and miR-194 Levels
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu