Molecular characterization of fecundity-related gene regions in some of Türkiye's native sheep breeds

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dc.authoridOzdil, Fulya/0000-0002-5298-6997
dc.contributor.authorAymaz, Ramazan
dc.contributor.authorOzdil, Fulya
dc.contributor.authorYaman, Yalcin
dc.date.accessioned2024-12-24T19:32:56Z
dc.date.available2024-12-24T19:32:56Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractIn this study, the BMP15 and GDF9 gene regions were examined through DNA sequencing in some native sheep breeds of Turkiye (Kivircik, Karacabey Merino, Chios, Gokceada, cine capari, Awassi, and Karakacan). In the BMP15 exon 2 region, two single nucleotide polymorphisms (SNPs) were identified: one synonymous SNP, P248P (proline/proline), and one nonsynonymous SNP, L251P (leucine/proline), resulting in a missense mutation. In the GDF9 exon 1 region, only a nonsynonymous SNP, R87H (histidine/ arginine), was found. In the GDF9 exon 2 region, four SNPs were identified: two nonsynonymous SNPs, E241K (glutamate/lysine) and V332I (valine/isoleucine), and two synonymous SNPs, L159L (leucine/leucine) and E326E (glutamate/glutamate). The identified haplotypes in the GDF9 gene region showed a high D' (linkage disequilibrium) value, indicating a strong association. Furthermore, a complete correlation was observed between the E326E and V332I variants in the studied breeds. The Chios breed exhibited significantly higher frequencies of heterozygosity for the E326E and V332I variants compared to the Kivircik and Karacabey Merino breeds. The heterozygosity frequencies for the E326E and V332I variants in the Kivircik, Karacabey Merino, and Chios breeds were determined to be 0.08, 0.13, and 0.46, respectively. The higher frequency of heterozygosity observed in E326E and V332I variants within the Chios breed suggests their association with the trait of multiple births.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Tekirdagbreve; Namik Kemal University [NKUBAP.03, YL.22.364]
dc.description.sponsorshipThis study was funded by the Scientific Research Projects Coordination Unit of Tekirda & gbreve; Namik Kemal University (project number: NKUBAP.03.YL.22.364) .
dc.identifier.doi10.55730/1300-0128.4334
dc.identifier.issn1300-0128
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85185176860
dc.identifier.scopusqualityQ3
dc.identifier.trdizinid1242623
dc.identifier.urihttps://doi.org/10.55730/1300-0128.4334
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1242623
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7893
dc.identifier.volume48
dc.identifier.wosWOS:001168267600002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Veterinary & Animal Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectBMP15 gene
dc.subjectGDF9 gene
dc.subjectmultiple births
dc.subjectsheep
dc.subjectSNP
dc.titleMolecular characterization of fecundity-related gene regions in some of Türkiye's native sheep breeds
dc.typeArticle

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