The determination of the carbonic anhydrases activators in vitro effect of mixed donor crown ethers

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dc.authoridCALISIR, Umit/0000-0001-7699-2008
dc.contributor.authorAkkemik, Ebru
dc.contributor.authorCicek, Baki
dc.contributor.authorCamadan, Yasemin
dc.contributor.authorCalisir, Umit
dc.contributor.authorOnbasioglu, Zekai
dc.date.accessioned2024-12-24T19:24:11Z
dc.date.available2024-12-24T19:24:11Z
dc.date.issued2018
dc.departmentSiirt Üniversitesi
dc.description.abstractCarbonic anhydrases (CAs) play an important function in various physiological and pathological processes. Therefore, many researchers work in this field in order to design and synthesize new drugs. Both inhibitors and activators of CAs, which are associated with the diagnosis and treatment of many diseases, are very important. The emergence of the use of CA activators in the treatment of Alzheimer has led many scholars to work on this issue. In this study, CA activators and inhibitors are determined. The crown ethers compounds (1, 2, 3, 6, 7, 8, and 9) were found to cause activation on enzyme activities of hCA I and II. The AC(50) values on hCA I and II of the compounds are in the range of 4.6565-374.979M. The 4 (IC50; 1.301 and 3.215M for hCA I and II) and 5 (IC50; 73.96 and 378.5M for hCA I and II) compounds were found to cause inhibition on enzyme activities of hCA I and II.
dc.identifier.doi10.1002/jbt.22032
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue3
dc.identifier.pmid29327806
dc.identifier.scopus2-s2.0-85044007215
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/jbt.22032
dc.identifier.urihttps://hdl.handle.net/20.500.12604/5884
dc.identifier.volume32
dc.identifier.wosWOS:000427566900002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Biochemical and Molecular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectactivation
dc.subjectcarbonic anhydrase
dc.subjectinhibition
dc.subjectmixed donor crown ether
dc.titleThe determination of the carbonic anhydrases activators in vitro effect of mixed donor crown ethers
dc.typeArticle

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