Well designed iridium-phosphinite complexes: Biological assays, electrochemical behavior and density functional theory calculations

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dc.authoridAssylbekova, Saniya/0000-0002-0492-5276
dc.contributor.authorRafikova, Khadichakhan
dc.contributor.authorMeric, Nermin
dc.contributor.authorBinbay, Nil Ertekin
dc.contributor.authorOkumus, Veysi
dc.contributor.authorErdem, Kemal
dc.contributor.authorBelyankova, Yelizaveta
dc.contributor.authorTursynbek, Saniya
dc.date.accessioned2024-12-24T19:27:44Z
dc.date.available2024-12-24T19:27:44Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractMononuclear phosphinite Iridium complexes based on ferrocene group have been prepared and characterized by various spectroscopic techniques. The complexes were subjected to cyclic voltammetry studies in order to determine the energies of HOMO and LUMO levels and to estimate their electrochemical and some electronic properties. Organic complex-based memory substrates were immobilized using TiO 2 -modified ITO electrodes, and the memory functions of phosphinite-based organic complexes were verified by chronoamperometry (CA) and open-circuit potential amperometry (OCPA). Extensive theoretical and experimental investigations were directed to gain a more profound understanding of the chemical descriptors and the diverse electronic transitions taking place within the iridium complexes, as well as their electrochemical characteristics. The quantum chemical calculations were carried out for the iridium complexes at the DFT/CAM-B3LYP level of theory in the gas phase. Furthermore, the antioxidant, antimicrobial, DNA binding, and DNA cleavage activities of the complexes were tested. Complex 2 exhibited the highest radical scavenging activity (67.5 +/- 2.24 %) at 200.0 mg/L concentration. It was observed that the complexes formed an inhibition zone in the range of 8-15 mm against Gram + bacteria and in the range of 0-13 mm against Gram - bacteria. The agarose gel electrophoresis method was used to determine the DNA binding and DNA cleavage activities of the complexes. All of the tested complexes had DNA binding activity; however, complexes 1, 2 , and 8 showed better binding activity than the others.
dc.description.sponsorshipScience Committee of the Ministry of Education and Science of the Republic of Kazakhstan [AP13068542]; Dicle University [FEN.24.006]
dc.description.sponsorshipThe research is funded by the Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan (Grant No: AP13068542) . Partial supports of this work by Dicle University (Project number: FEN.24.006) is gratefully acknowledged.
dc.identifier.doi10.1016/j.saa.2024.124448
dc.identifier.issn1386-1425
dc.identifier.issn1873-3557
dc.identifier.pmid38763019
dc.identifier.scopus2-s2.0-85193423872
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.saa.2024.124448
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6769
dc.identifier.volume318
dc.identifier.wosWOS:001264110300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofSpectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectPhosphinite ligand
dc.subjectIridium
dc.subjectDFT calculation
dc.subjectBiological assays
dc.subjectFerrocene group
dc.subjectElectrochemical behavior
dc.titleWell designed iridium-phosphinite complexes: Biological assays, electrochemical behavior and density functional theory calculations
dc.typeArticle

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