Doxycycline and meloxicam can treat neuroinflammation by increasing activity of antioxidant enzymes in rat brain

Basit Öğe Kaydı
dc.authoridBAHCIVAN, Emre/0000-0002-4415-1738
dc.contributor.authorDik, Burak
dc.contributor.authorCoskun, Devran
dc.contributor.authorBahcivan, Emre
dc.contributor.authorEr, Ayse
dc.date.accessioned2024-12-24T19:33:21Z
dc.date.available2024-12-24T19:33:21Z
dc.date.issued2019
dc.departmentSiirt Üniversitesi
dc.description.abstractThe aim of this study is to determine the effects of alone or combined usage of doxycycline and meloxicam on brain superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), and matrix metalloproteinase (MMP)-9 levels of lipopolysaccharide (LPS)-induced brain inflammation. Totally 78 rats were divided into 5 groups; Healthy control (n=6), LPS (n=18, 0.05 mu g/mu L/rat, intracranially), LPS+D (n=18, LPS 0.05 mu g/mu L/rat, intracranially and doxycycline 40 mg/kg, intraperitoneally), LPS+M (n=18, LPS 0.05 mu g/mu L/rat, intracranially and meloxicam 2 mg/kg, intraperitoneally), LPS+Combination (n=18, LPS 0.05 mu g/mu L/rat, intracranially and simultaneously both drug combination) groups. Animals were euthanized at 1, 3 and 6 hours following injections and the brains were removed. Brain SOD, CAT, MDA and MMP-9 levels were determined by ELISA reader. Parameters of LPS groups generally different from Healthy control group. When compared to LPS group, increased SOD level of LPS+D at 3 hours and CAT levels of LPS+M and LPS+D groups were determined (P<0.05) at 3 and 6 hours, respectively. In addition, all treatments statistically significantly (P<0.05) decreased MMP-9 levels at 6 hours. In conclusion, doxycycline and meloxicam may show antioxidant effect via increasing antioxidant enzyme production in the brain; however combined usage of drugs may show more beneficial effect for neuroinflammation.
dc.identifier.endpage396
dc.identifier.issn1011-601X
dc.identifier.issue1
dc.identifier.pmid30852475
dc.identifier.scopus2-s2.0-85062684469
dc.identifier.scopusqualityQ3
dc.identifier.startpage391
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8098
dc.identifier.volume32
dc.identifier.wosWOS:000463981600004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherUniv Karachi
dc.relation.ispartofPakistan Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectAntioxidants
dc.subjectdoxycycline
dc.subjectmeloxicam
dc.subjectneuroinflammation
dc.titleDoxycycline and meloxicam can treat neuroinflammation by increasing activity of antioxidant enzymes in rat brain
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu