Effects of daily propylene glycol drenching during the Ovsynch protocol on fertility and metabolic parameters in lactating dairy cows

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dc.authoridGumen, Ahmet/0000-0002-3607-4365
dc.authoridOrman, Abdulkadir/0000-0001-9138-4422
dc.authoridKarakaya-Bilen, Ebru/0000-0003-4837-1858
dc.authoridCakircali, Rabia/0000-0001-8470-0116
dc.contributor.authorCakircali, Rabia
dc.contributor.authorKarakaya-Bilen, Ebru
dc.contributor.authorGuner, Baris
dc.contributor.authorMecitoglu, Zafer
dc.contributor.authorOrtac, Cihan Tolga
dc.contributor.authorKeskin, Abdulkadir
dc.contributor.authorOrman, Abdulkadir
dc.date.accessioned2024-12-24T19:29:36Z
dc.date.available2024-12-24T19:29:36Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractNegative energy balance (NEB) caused by restricted feed intake leads to body condition loss (BCS), increased metabolic stress and reduced fertility in dairy cows. Propylene glycol (PG) is a precursor of ruminal propionate for gluconeogenesis used to increase metabolic adaptation to the early postpartum period. The aim of this study was to determine the effects of daily drenching of PG during the fixed-time artificial insemination (FTAI) protocol on beta-hydroxybutyric acid (BHBA), glucose, adiponectin, insulin-like growth factor-1 (IGF1) concentrations, follicle size and pregnancy rate in dairy cows. Cows (n = 148) were randomly divided into two groups and received either 300 mL of PG (PG-OVS, n = 76) or 300 mL of water (CON- -OVS, n = 72) each day of the Ovsynch protocol (GnRH-7 days-PGF2a-56 hours-GnRH-16-18-hour FTAI) between days 57 +/- 3 to 67 +/- 3 postpartum for the first service. Body condition scores (14 days before expected calving, at calving, on days 21 and 42 postpartum) were recorded. Blood samples were collected days 7 +/- 3, 21 +/- 3 postpartum, at the beginning of the Ovsynch (days 57 +/- 3) and at the time of FTAI (days 67 +/- 3) for measurements of BHBA, glucose, adiponectin and IGF1 concentrations. Ultrasonographic examinations were done to measure follicle size at the beginning of Ovsynch and FTAI and to determine pregnancy on days 30 and 60 following FTAI. There were no differences (p >.05) in glucose, adiponectin and IGF1 concentrations between the groups during the study. Although there was no difference ( p >.05) in BHBA concentrations on postpartum day 7 +/- 3, 21 +/- 3 and 57 +/- 3 between the groups, BHBA concentrations at the time of insemination was lower (p <.05) in the PG-OVS group (0.72 +/- 0.03 mmol/L) than in the CON-OVS group (0.81 +/- 0.03 mmol/L). Follicle sizes at the beginning of Ovsynch (PG-OVS, 14.5 +/- 0.48 mm; CON-OVS, 14.3 +/- 0.59 mm) and FTAI (PG-OVS, 17.8 +/- 0.52 mm; CON-OVS, 17.7 +/- 0.42 mm) were not different ( p <.05). Pregnancy rate of the cows in the PG-OVS group (46.1%, 35/76) was higher (p =.05) than in the CON-OVS group (30.6%, 22/72) on day 30 following FTAI. In conclusion, decreasing serum BHBA concentrations at the time of FTAI by means of daily drenching of PG during the Ovsynch protocol, increased the pregnancy rate at first service in lactating dairy cows. On the other hand, blood glucose was not related with pregnancy rates in our study, probably as a result of our sampling time and more rapid fluctuations of blood glucose concentrations when compared to BHBA.
dc.description.sponsorship~University of Uludag Scientific Research Projects Council [KUAP(V)-2019/1]
dc.description.sponsorshipUniversity of Uludag Scientific Research Projects Council, Grant/Award Number: KUAP(V)-2019/1
dc.identifier.doi10.1111/rda.14405
dc.identifier.endpage1103
dc.identifier.issn0936-6768
dc.identifier.issn1439-0531
dc.identifier.issue8
dc.identifier.pmid37307275
dc.identifier.scopus2-s2.0-85162250807
dc.identifier.scopusqualityQ2
dc.identifier.startpage1097
dc.identifier.urihttps://doi.org/10.1111/rda.14405
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7163
dc.identifier.volume58
dc.identifier.wosWOS:001013517300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofReproduction in Domestic Animals
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectBHBA
dc.subjectdairy cow
dc.subjectfertility
dc.subjectOvsynch
dc.subjectpropylene glycol
dc.titleEffects of daily propylene glycol drenching during the Ovsynch protocol on fertility and metabolic parameters in lactating dairy cows
dc.typeArticle

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