Effects of Thymus vulgaris Oil on Sodium Hypochlorite-Induced Damage in Rats

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dc.contributor.authorBolatli, Guenes
dc.contributor.authorTas, Fatih
dc.contributor.authorAlayunt, Naci Omer
dc.date.accessioned2024-12-24T19:33:43Z
dc.date.available2024-12-24T19:33:43Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractWe aimed to determine the potential damage mechanisms of exposure to widely used sodium hypochlorite (NaOCl) and the effects of Thymus vulgaris on this exposure. Rats were divided into six groups: control, T. vulgaris, 4% NaOCl, 4% NaOCl + T. vulgaris, 15% NaOCl, and 15% NaOCl + T. vulgaris. Serum and lung tissue samples were taken after applying NaOCl and T. vulgaris by inhalation twice a day for 30 min for four weeks. The samples were examined biochemically (TAS/TOS), histopathologically, and immunohistochemically (TNF-alpha). In serum TOS values, the mean of 15% NaOCl was significantly higher than in 15% NaOCl + T. vulgaris. This was the opposite in terms of serum TAS values. Histopathologically, there was a significant increase in lung injury in 15% NaOCl; significant improvement was observed in 15% NaOCl + T. vulgaris. Immunohistochemically, there was a significant increase in TNF-alpha expression in both 4% NaOCl and 15% NaOCl; significant decreases were observed in both 4% NaOCl + T. vulgaris and 15% NaOCl + T. vulgaris. The use of sodium hypochlorite, which is harmful to the lungs and is widely used in homes and industries, should be limited. In addition, using T. vulgaris essential oil by inhalation may protect against the harmful effects of sodium hypochlorite.
dc.description.sponsorshipSiirt University Scientific Research Project Office [2021-SIUTIP-061]
dc.description.sponsorshipThe study was supported by the Siirt University Scientific Research Project Office (No: 2021-SIUTIP-061).
dc.identifier.doi10.3390/molecules28052164
dc.identifier.issn1420-3049
dc.identifier.issue5
dc.identifier.pmid36903410
dc.identifier.scopus2-s2.0-85149895766
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/molecules28052164
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8251
dc.identifier.volume28
dc.identifier.wosWOS:000948068800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectsodium hypochlorite
dc.subjectT
dc.subjectvulgaris
dc.subjectinhalation
dc.subjectTNF-alpha
dc.subjectTAS
dc.subjectTOS
dc.titleEffects of Thymus vulgaris Oil on Sodium Hypochlorite-Induced Damage in Rats
dc.typeArticle

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