The effect of fucoidan on the changes of some biochemical parameters and protein electrophoresis in hepatotoxicity induced by carbontetrachloride in rats

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dc.contributor.authorAysin, Nesrullah
dc.contributor.authorMert, Handan
dc.contributor.authorMert, Nihat
dc.contributor.authorIrak, Kivanc
dc.date.accessioned2024-12-24T19:30:32Z
dc.date.available2024-12-24T19:30:32Z
dc.date.issued2018
dc.departmentSiirt Üniversitesi
dc.description.abstractFucoidan is a sulfate polysaccharide extracted from brown algae. Fucoidan has various pharmacological properties, such as anti-tumor, anti-mutagenic, anti-inflammatory, antiviral, antioxidant, anti-fibrogenic activity and anti-complementary activities Objective: This study was aimed to explore the effect of fucoidan on biochemical parameters (ALT, AST, GGT, total protein, albumin, globulin) and protein fractions in hepatotoxicity induced by CCl4 in rats. Materials and Methods: The rats used in the study were randomly divided into four groups of 8 rats each: Control group, fucoidan group, fucoidan+CCl4 group and CCl4 group. After 24 hours from the process of an eight-day experiment, blood samples were taken. The analysis of ALT, AST, GGT activities and total protein, albumin, globulin levels were done by an autoanalyser and serum protein fractions (albumin, alpha 1- globulin, alpha 2-globulin beta- globulin, gamma- globulin and A/G ratio) were electrophoretically determined. Results: In the group of fucoidan+CCl4, it was determined that the levels of AST (p<0.001), GGT (p<0.001), total protein (p<0.01), globulin (p<0.01), beta-globulin % (p<0.01), gamma-globulin % (p<0.001) statistically decreased compared to CCl4 group. Conclusion: It can be said that fucoidan has the property of hepatoprotectant by looking to some biochemical parameters and changes in protein fractions that examined in hepatotoxicity induced by CCl4.
dc.identifier.doi10.18805/ijar.v0iOF.9131
dc.identifier.endpage542
dc.identifier.issn0367-6722
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85046718638
dc.identifier.scopusqualityQ3
dc.identifier.startpage538
dc.identifier.urihttps://doi.org/10.18805/ijar.v0iOF.9131
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7571
dc.identifier.volume52
dc.identifier.wosWOS:000430655800012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAgricultural Research Communication Centre
dc.relation.ispartofIndian Journal of Animal Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectCCl4
dc.subjectEnzymes
dc.subjectFucoidan
dc.subjectHepatotoxicity
dc.subjectProtein electrophoresis
dc.titleThe effect of fucoidan on the changes of some biochemical parameters and protein electrophoresis in hepatotoxicity induced by carbontetrachloride in rats
dc.typeArticle

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