The effect of fucoidan on the changes of some biochemical parameters and protein electrophoresis in hepatotoxicity induced by carbontetrachloride in rats
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Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Agricultural Research Communication Centre
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Fucoidan is a sulfate polysaccharide extracted from brown algae. Fucoidan has various pharmacological properties, such as anti-tumor, anti-mutagenic, anti-inflammatory, antiviral, antioxidant, anti-fibrogenic activity and anti-complementary activities Objective: This study was aimed to explore the effect of fucoidan on biochemical parameters (ALT, AST, GGT, total protein, albumin, globulin) and protein fractions in hepatotoxicity induced by CCl4 in rats. Materials and Methods: The rats used in the study were randomly divided into four groups of 8 rats each: Control group, fucoidan group, fucoidan+CCl4 group and CCl4 group. After 24 hours from the process of an eight-day experiment, blood samples were taken. The analysis of ALT, AST, GGT activities and total protein, albumin, globulin levels were done by an autoanalyser and serum protein fractions (albumin, alpha 1- globulin, alpha 2-globulin beta- globulin, gamma- globulin and A/G ratio) were electrophoretically determined. Results: In the group of fucoidan+CCl4, it was determined that the levels of AST (p<0.001), GGT (p<0.001), total protein (p<0.01), globulin (p<0.01), beta-globulin % (p<0.01), gamma-globulin % (p<0.001) statistically decreased compared to CCl4 group. Conclusion: It can be said that fucoidan has the property of hepatoprotectant by looking to some biochemical parameters and changes in protein fractions that examined in hepatotoxicity induced by CCl4.
Açıklama
Anahtar Kelimeler
CCl4, Enzymes, Fucoidan, Hepatotoxicity, Protein electrophoresis
Kaynak
Indian Journal of Animal Research
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
52
Sayı
4
