Evaluation of oxidant and intracellular anti-oxidant activity in rheumatoid arthritis patients: In vivo and in silico studies

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dc.authoridGUR, Fatma/0000-0001-5983-1472
dc.authoridCENGIZ, Mustafa/0000-0002-6925-8371
dc.contributor.authorOgul, Yasemin
dc.contributor.authorGur, Fatma
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorGur, Bahri
dc.contributor.authorSari, Refik Ali
dc.contributor.authorKiziltunc, Ahmet
dc.date.accessioned2024-12-24T19:27:20Z
dc.date.available2024-12-24T19:27:20Z
dc.date.issued2021
dc.departmentSiirt Üniversitesi
dc.description.abstractRheumatoid Arthritis (RA) is the most prevalent cause of the systematic inflammatory arthritis that destroys the joints. While the pathogenesis of RA remains to be clarified, the imbalance in the oxidant and anti-oxidant defense system plays a crucial role. This study aims to evaluate oxidant and anti-oxidant levels of RA patients and their impacts on the activity of the disease via in silico studies. 28 patients who had not previously received any treatment for RA and 20 healthy controls were included. Their oxidative stress markers, antioxidant markers, and inflammatory factors were investigated via in silico studies. Compared to the Control Group, serum CRP levels, MDA levels, and XO activities were higher in RA Group. Cu/ZnSOD and GPx activities decreased while CAT activities remained unchanged. Besides, there was a positive correlation between MDA-serum CRP levels but a negative correlation between MDA levels-Cu/ZnSOD activities. Furthermore, we observed a negative correlation between CRP levels and Cu/ZnSOD activities. Based on these results, it was concluded that oxidative stress had increased, the defense system had weakened, and ROS production had increased. Finally, our study results with SOD and CAT activity were confirmed by molecular docking studies.
dc.description.sponsorshipAtaturk University
dc.description.sponsorshipThe author thanks Ataturk University for its generous support.
dc.identifier.doi10.1016/j.intimp.2021.107654
dc.identifier.issn1567-5769
dc.identifier.issn1878-1705
dc.identifier.pmid33895477
dc.identifier.scopus2-s2.0-85104808938
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.intimp.2021.107654
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6604
dc.identifier.volume97
dc.identifier.wosWOS:000679160500006
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Immunopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectRheumatoid arthritis
dc.subjectCellular damage
dc.subjectMolecular modeling
dc.subjectOxidative stress
dc.titleEvaluation of oxidant and intracellular anti-oxidant activity in rheumatoid arthritis patients: In vivo and in silico studies
dc.typeArticle

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