Investigation of antibacterial, antifungal, and antioxidant activities in novel poly(DEAEMA-co-EMA)/polyindole composites

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dc.contributor.authorSafiye Elif Korcan
dc.contributor.authorCengiz Soykan
dc.contributor.authorBurak Tüfekçi
dc.contributor.authorNaci Ömer Alayunt
dc.contributor.authorŞah İsmail Çivi
dc.date.accessioned2025-04-16T07:48:13Z
dc.date.available2025-04-16T07:48:13Z
dc.date.issued2025-03-29
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractIn the current study, in the first stage, amphiphilic poly(2-diethylamino ethylmethacrylate-co-ethyl methacrylate) [Poly(DEAEMA-co-EMA)] was synthesized from the 2-diethylamino ethylmethacrylate (DEAEMA) and the ethyl methacrylate (EMA) using the free radical polymerization method. In the second stage, five series of composites were prepared at different concentrations using the indole conductive monomer in the presence of iron(III) chloride (FeCl3) using the in situ oxidative polymerization technique in poly(DEAEMA-co-EMA) copolymer. Scanning electron microscope and Atomic force microscope images proved the homogeneous structure of the composites, and Fourier transform infrared spectroscopy analysis of the composite has shown that it has been produced successfully. The antimicrobial activity of the prepared poly(DEAEMA-co-EMA)/PIN composites was evaluated. Moreover, antioxidant studies of the composites were carried out. The results showed that the enhanced bioactivity of poly(DEAEMA-co-EMA)/PIN(90%) composite. In this study, all poly(DEAEMA-co-EMA)/PIN composites and polymers showed antibacterial activity against Streptococcus mutans. PCs had more antifungal activity against Aspergillus flavus than PIN, Poly(DEAEMA), and poly(DEAEMA-co-EMA). The antimicrobial activity of PCs was enhanced by increasing the permeability of the cell membrane with DEAEMA. It was determined that the antibacterial activity increased in direct proportion to the indole concentration. OSI values of PIN, Poly(DEAEMA), and poly(DEAEMA-co-EMA), and PCs ranged between 1.3513 and 0.1183. Highlights: Conductive Polymer Composites are a special commercial polymer composite class due to their biological properties. Discusses morphological properties of poly(DEAEMA-co-EMA)/PIN composites. Summarizes antimicrobial and antioxidant activities of poly(DEAEMA-co-EMA)/PIN composites. Demonstrate the high antimicrobial activity of Poly(DEAEMA-co-EMA)/PIN composites against S. mutans. Determine that Poly(DEAEMA-co-EMA)/PIN composites have antioxidant capacity.
dc.identifier.doi10.1002/pen.27207
dc.identifier.issn0032-3888
dc.identifier.issn1548-2634
dc.identifier.scopus2-s2.0-105001867303
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/pen.27207
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8611
dc.identifier.wos001459836200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorTüfekçi, Burak
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofPolymer Engineering & Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectantibacterial activity
dc.subjectantifungal effects
dc.subjectantioxidant studies
dc.subjectbiomaterials
dc.subjectpolyindole
dc.subjectpolymer matrix composites
dc.titleInvestigation of antibacterial, antifungal, and antioxidant activities in novel poly(DEAEMA-co-EMA)/polyindole composites
dc.typejournal-article

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