In Silico Evaluation of the Haplotype Diversity, Phylogenetic Variation and Population Structure of Human E. granulosus sensu stricto (G1 Genotype) Sequences

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dc.authoridCao, Jianping/0000-0002-1974-0047
dc.authoridMUHAMMED AHMED, SELCUK/0000-0003-1769-4558
dc.authoridSimsek, Sami/0000-0002-3567-326X
dc.contributor.authorSelcuk, Muhammed Ahmed
dc.contributor.authorCelik, Figen
dc.contributor.authorKesik, Harun Kaya
dc.contributor.authorKilinc, Seyma Gunyakti
dc.contributor.authorAhmed, Haroon
dc.contributor.authorJiang, Nan
dc.contributor.authorSimsek, Sami
dc.date.accessioned2024-12-24T19:33:43Z
dc.date.available2024-12-24T19:33:43Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractEchinococcus granulosus sensu lato is the causative agent of cystic echinococcosis (CE), which is a neglected zoonotic disease with an important role in human morbidity. In this study, we aimed to investigate the haplotype diversity, genetic variation, population structure and phylogeny of human E. granulosus sensu stricto (s.s.) (G1 genotype) isolates submitted to GenBank from different parts of the world by sequencing the mitochondrial CO1 and ND1 genes. The sequences of the mt-CO1 (401 bp; n = 133) and mt-ND1 (407 bp; n = 140) genes were used to analyze the haplotype, polymorphism and phylogenetic of 273 E. granulosus s.s. (G1 genotype) isolates. Mutations were observed at 31 different points in the mt-CO1 gene sequences and at 100 different points in the mt-ND1 gene sequences. Furthermore, 34 haplotypes of the mt-CO1 sequences and 37 haplotypes of the mt-ND1 sequences were identified. Tajima's D, Fu's Fs, and Fu's LD values showed high negative values in both mt-CO1 and mt-ND1 gene fragments. The haplotype diversities in the sequences retrieved from GenBank in this study indicate that the genetic variation in human isolates of E. granulosus s.s. in western countries is higher than in eastern countries. This may be due to demographic expansions due to animal trades and natural selections.
dc.description.sponsorshipNational Natural Science Foundation of China [81971969, 82272369, 81772225]; Three-Year Public Health Action Plan of Shanghai [GWV-10.1-XK13]
dc.description.sponsorshipThis study was supported by the National Natural Science Foundation of China (Nos. 81971969, 82272369, and 81772225 to J.C.) and the Three-Year Public Health Action Plan (2020-2022) of Shanghai (No. GWV-10.1-XK13 to J.C.). The funders had no role in the study design, the data collection, and analysis, the decision to publish, or the preparation of the manuscript.
dc.identifier.doi10.3390/pathogens11111346
dc.identifier.issn2076-0817
dc.identifier.issue11
dc.identifier.pmid36422598
dc.identifier.scopus2-s2.0-85149581606
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/pathogens11111346
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8254
dc.identifier.volume11
dc.identifier.wosWOS:000895602400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofPathogens
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectEchinococcus granulosus s.s.
dc.subjectG1 genotype
dc.subjectCO1
dc.subjectND1
dc.subjectgenetic variability
dc.titleIn Silico Evaluation of the Haplotype Diversity, Phylogenetic Variation and Population Structure of Human E. granulosus sensu stricto (G1 Genotype) Sequences
dc.typeArticle

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