Therapeutic role of boron on acrylamide-induced nephrotoxicity, cardiotoxicity, neurotoxicity, and testicular toxicity in rats: Effects on Nrf2/Keap-1 signaling pathway and oxidative stress

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dc.authoridCENGIZ, Mustafa/0000-0002-6925-8371
dc.contributor.authorGur, Fatma
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorGur, Bahri
dc.contributor.authorCengiz, Osman
dc.contributor.authorSaricicek, Osman
dc.contributor.authorAyhanci, Adnan
dc.date.accessioned2024-12-24T19:27:28Z
dc.date.available2024-12-24T19:27:28Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractBackground: Acrylamide (ACR) is a heat-related carcinogen used in cooking some foods as well as in other thermal treatments. The present study aims to investigate the possible protective effect of boron (BA) against ACR-induced toxicity of kidney, brain, heart, testis, and bladder tissues in rats. Methods: Rats have been divided into 5 equal groups: Control (saline), ACR (38.27 mg/kg), BA (20 mg/kg), BA+ ACR (10 mg/kg + ACR), and BA+ ACR (20 mg/kg BA+ACR). Kidney tissue from rats was collected and the levels of malondialdehyde (MDA), glutathione (GSH), and the activity of superoxide dismutase (SOD) were measured. In addition, the kidneys of these animals, as well as the brain, heart, testes, and bladder tissues were examined for possible histological changes. Total Nrf2 and Keap-1 protein expression in kidney, heart, and testis tissues was examined by immunohistochemistry. Results: While significant increases in MDA levels were observed in the kidneys of rats receiving ACR alone, significant decreases in antioxidant markers (SOD and GSH) were observed. Besides, kidney, brain, heart, and testicular tissues were analyzed and damage was observed in the groups receiving ACR. However, no significant histologic changes were noted in the bladder tissue. Both dosages of BA in combination with ACR improved the changes in ACR-induced antioxidant tissue parameters. Despite the fact that MDA levels were decreased with these two dosages, histological structural abnormalities were found to be greatly improved. Conclusion: Our results show that BA has a strong protective effect on ACR-induced multi-organ toxicity. The study results show that BA could be a potential element to reduce ACR toxicity to which we are often exposed.
dc.description.sponsorshipSiirt University, Scientific Research Projects Unit [2021-S.IUE.GT-17]; Ataturk University, Scientific Research Projects Unit [TYL-2022-9618 BAP]
dc.description.sponsorshipThe others would like to thank Siirt University, Scientific Research Projects Unit (2021-S.IUE.GT-17) and Ataturk University, Scientific Research Projects Unit (TYL-2022-9618 BAP) for their support of our study.
dc.identifier.doi10.1016/j.jtemb.2023.127274
dc.identifier.issn0946-672X
dc.identifier.issn1878-3252
dc.identifier.pmid37562273
dc.identifier.scopus2-s2.0-85166985363
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jtemb.2023.127274
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6645
dc.identifier.volume80
dc.identifier.wosWOS:001064862200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Gmbh
dc.relation.ispartofJournal of Trace Elements in Medicine and Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectAcrylamide
dc.subjectBoric acid
dc.subjectKidney damage
dc.subjectNfr2/Keap-1
dc.subjectRats
dc.titleTherapeutic role of boron on acrylamide-induced nephrotoxicity, cardiotoxicity, neurotoxicity, and testicular toxicity in rats: Effects on Nrf2/Keap-1 signaling pathway and oxidative stress
dc.typeArticle

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