Differential expression of angiogenesis-related genes in goat uterus and corpus luteum during pregnancy

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dc.authoridTURGUT, Ali Osman/0000-0001-6863-0939
dc.contributor.authorTurgut, Ali Osman
dc.contributor.authorAgaoglu, Ozgecan Korkmaz
dc.date.accessioned2024-12-24T19:29:36Z
dc.date.available2024-12-24T19:29:36Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractVascularization and the control of luteal and endometrial development are regulated by hypoxia-inducible factors (HIFs) and vascular endothelial growth factor (VEGF) during pregnancy. In this study, the mRNA and protein expression levels of HIFs (HIF1A, HIF2A and HIF3A) and VEGF in goat uterine and ovarian tissues during various stages of pregnancy were evaluated. A total of 42 Hair goats were used and were allocated into six groups, namely embryo-positive (G1), early pregnancy (G2), mid-term pregnancy (G3), late pregnancy (G4), oocyte-positive group (G5) and diestrus group (G6). The mRNA expression of the examined genes was evaluated by RT-qPCR, and protein expression was evaluated by immunohistochemistry (IHC). In caruncles, HIF1A mRNA expression was greater in G1, G2 and G4 than in G3 (p < .05). HIF1A and HIF2A expression was greater in G1 than in G5 (p < .05). In cotyledons, HIF1A, HIF2A and HIF3A mRNA expression was greater in G2 and G3 compared to G4 (p < .05). In luteal tissue, HIF1A mRNA expression was greater in G1 and G2 than in G3 and G4 (p < .05). In the immunohistochemical examination, HIF1A, HIF2A, HIF3A and VEGF immunoreactions were detected in uterine and luteal tissues. Findings suggest that HIFs and VEGF are involved in the regulation of ovarian functions as well as the processes of implantation and placentation.
dc.description.sponsorshipScientific and Technological Research Council of Turkey [TUBITAK-1001, 117O613]
dc.description.sponsorshipThe Scientific and Technological Research Council of Turkey, Grant/Award Number: TUBITAK-1001(Project No and 117O613)
dc.identifier.doi10.1111/rda.14482
dc.identifier.endpage1684
dc.identifier.issn0936-6768
dc.identifier.issn1439-0531
dc.identifier.issue12
dc.identifier.pmid37776186
dc.identifier.scopus2-s2.0-85173449622
dc.identifier.scopusqualityQ2
dc.identifier.startpage1672
dc.identifier.urihttps://doi.org/10.1111/rda.14482
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7164
dc.identifier.volume58
dc.identifier.wosWOS:001078241000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofReproduction in Domestic Animals
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectcorpus luteum
dc.subjectgoat
dc.subjecthypoxia-inducible factors
dc.subjectuterus
dc.subjectvascular endothelial growth factor
dc.titleDifferential expression of angiogenesis-related genes in goat uterus and corpus luteum during pregnancy
dc.typeArticle

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