Evaluation of Carbonic Anhydrase, Acetylcholinesterase, Butyrylcholinesterase, and ?-Glycosidase Inhibition Effects and Antioxidant Activity of Baicalin Hydrate

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dc.authoridKARAGECILI, HASAN/0000-0001-6912-3998
dc.contributor.authorDurmaz, Lokman
dc.contributor.authorKaragecili, Hasan
dc.contributor.authorGulcin, Ilhami
dc.date.accessioned2024-12-24T19:33:42Z
dc.date.available2024-12-24T19:33:42Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractBaicalin is the foremost prevalent flavonoid found in Scutellaria baicalensis. It also frequently occurs in many multi-herbal preparations utilized in Eastern countries. The current research has assessed and compared the antioxidant, antidiabetic, anticholinergic, and antiglaucoma properties of baicalin hydrate. Baicalin hydrate was tested for its antioxidant capacity using a variety of techniques, including N,N-dimethyl-p-phenylenediamine dihydrochloride radical (DMPD center dot+) scavenging activity, 2,2 '-azinobis-(3-ethylbenzothiazoline-6-sulphonate) radical (ABTS(center dot+)) scavenging activity, 1,1-diphenyl-2-picrylhydrazyl radical (DPPH center dot) scavenging activity, potassium ferric cyanide reduction ability, and cupric ions (Cu2+) reducing activities. Also, for comparative purposes, reference antioxidants, such as butylated hydroxyanisole (BHA), Trolox, alpha-Tocopherol, and butylated hydroxytoluene (BHT) were employed. Baicalin hydrate had an IC50 value of 13.40 mu g/mL (r(2): 0.9940) for DPPH radical scavenging, whereas BHA, BHT, Trolox, and alpha-Tocopherol had IC50 values of 10.10, 25.95, 7.059, and 11.31 mu g/mL for DPPH center dot scavenging, respectively. These findings showed that baicalin hydrate had comparably close and similar DPPH center dot scavenging capability to BHA, alpha-tocopherol, and Trolox, but it performed better than BHT. Additionally, apart from these studies, baicalin hydrate was tested for its ability to inhibit a number of metabolic enzymes, including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase II (CA II), and alpha-glycosidase, which have been linked to several serious illnesses, such as Alzheimer's disease (AD), glaucoma, and diabetes, where the K-i values of baicalin hydrate toward the aforementioned enzymes were 10.01 +/- 2.86, 3.50 +/- 0.68, 19.25 +/- 1.79, and 26.98 +/- 9.91 nM, respectively.
dc.description.sponsorshipTurkish Academy of Sciences (TBA)
dc.description.sponsorshipNo Statement Available
dc.identifier.doi10.3390/life13112136
dc.identifier.issn2075-1729
dc.identifier.issue11
dc.identifier.pmid38004276
dc.identifier.scopus2-s2.0-85180471502
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/life13112136
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8229
dc.identifier.volume13
dc.identifier.wosWOS:001123322300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofLife-Basel
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectbaicalin hydrate
dc.subjectacetylcholinesterase
dc.subjectantioxidant activity
dc.subjectalpha-glycosidase
dc.subjectbutyrylcholinesterase
dc.subjectcarbonic anhydrase
dc.subjectphenolic compounds
dc.titleEvaluation of Carbonic Anhydrase, Acetylcholinesterase, Butyrylcholinesterase, and ?-Glycosidase Inhibition Effects and Antioxidant Activity of Baicalin Hydrate
dc.typeArticle

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