Effect of ketoprofen and tolfenamic acid on intravenous pharmacokinetics of ceftriaxone in sheep

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dc.authoridUney, Kamil/0000-0002-8674-4873
dc.authoridCoskun, Devran/0000-0003-1151-1861
dc.authoridAtik, Orkun/0000-0003-2411-7492
dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.contributor.authorCetin, Gul
dc.contributor.authorDurna Corum, Duygu
dc.contributor.authorCorum, Orhan
dc.contributor.authorAtik, Orkun
dc.contributor.authorCoskun, Devran
dc.contributor.authorUney, Kamil
dc.date.accessioned2024-12-24T19:29:35Z
dc.date.available2024-12-24T19:29:35Z
dc.date.issued2021
dc.departmentSiirt Üniversitesi
dc.description.abstractIn this study, the pharmacokinetics of ceftriaxone (40 mg/kg) was determined following a single intravenous (IV) administration of ceftriaxone alone and co-administration with ketoprofen (3 mg/kg) or tolfenamic acid (2 mg/kg) in sheep. Eight healthy Akkaraman sheep (2.4 +/- 0.3 years and 44 +/- 4 kg of body weight) were used. The study was carried out according to the longitudinal design in three periods with a 15-day washout period between administrations. In the first period, sheep received ceftriaxone alone via an IV injection. In the second and third periods, the same sheep received ceftriaxone in combination with ketoprofen and tolfenamic acid, respectively. Plasma concentrations of ceftriaxone were assayed by high-performance liquid chromatography and analyzed using non-compartmental analysis. Following the administration of ceftriaxone alone, the elimination half-life (t(1/2 lambda z)), area under the plasma concentration-time curve from zero (0) hours to infinity (infinity) (AUC(0-infinity)), total clearance (Cl-T), and volume of distribution at steady state were 1.42 h, 182.41 h*mu g/ml, 0.22 L/h/kg, and 0.17 L/kg, respectively. While ketoprofen and tolfenamic acid significantly increased the t(1/2 lambda z) and AUC(0-infinity) of ceftriaxone, they significantly reduced the Cl-T. Ceftriaxone (40 mg/kg, IV) in concurrent use with ketoprofen and tolfenamic acid can be administrated at the 12 h dosing intervals to maintain T> minimum inhibitory concentration (MIC) values above 60% in the treatment of infections caused by susceptible pathogens with the MIC value of <= 0.75 and <= 1 mu g/mL, respectively, in sheep with an inflammatory condition.
dc.description.sponsorshipCoordination of Scientific Research Projects, University of Erzincan Binali Yildirim, Turkey [TSA-2019-522]
dc.description.sponsorshipThe Coordination of Scientific Research Projects, University of Erzincan Binali Yildirim, Turkey (Project No. TSA-2019-522)
dc.identifier.doi10.1111/jvp.13001
dc.identifier.endpage951
dc.identifier.issn0140-7783
dc.identifier.issn1365-2885
dc.identifier.issue6
dc.identifier.pmid34312894
dc.identifier.scopus2-s2.0-85111259601
dc.identifier.scopusqualityQ1
dc.identifier.startpage945
dc.identifier.urihttps://doi.org/10.1111/jvp.13001
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7146
dc.identifier.volume44
dc.identifier.wosWOS:000678980300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectceftriaxone
dc.subjectketoprofen
dc.subjectpharmacokinetics
dc.subjectsheep
dc.subjecttolfenamic acid
dc.titleEffect of ketoprofen and tolfenamic acid on intravenous pharmacokinetics of ceftriaxone in sheep
dc.typeArticle

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