Pharmacokinetics of carprofen following single and repeated intravenous administrations of different doses in sheep

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dc.authoridUney, Kamil/0000-0002-8674-4873
dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.authoridCoskun, Devran/0000-0003-1151-1861
dc.contributor.authorCorum, Orhan
dc.contributor.authorCoskun, Devran
dc.contributor.authorCorum, Duygu Durna
dc.contributor.authorIder, Merve
dc.contributor.authorYildiz, Ramazan
dc.contributor.authorOk, Mahmut
dc.contributor.authorUney, Kamil
dc.date.accessioned2024-12-24T19:29:35Z
dc.date.available2024-12-24T19:29:35Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractThe aim of this study was to determine the pharmacokinetics of carprofen following single and repeated intravenous (IV) administrations at 1.4 and 4 mg/kg doses in sheep. The study was carried out on twelve sheep in two experiments as single- and multiple-dose pharmacokinetics. In experiment 1, carprofen was administered via IV at single doses of 1.4 (n = 6) and 4 mg/kg (n = 6) in a randomized parallel design. In experiment 2, the same dose groups in experiment 1 following the 21-day washout period received intravenously carprofen every 24 h for 5 days. Plasma concentrations were measured using high-performance liquid chromatography-UV and analyzed by a two-compartment open model. After the single administration of 1.4 mg/kg dose, the t(1/2 alpha), t(1/2el), MRT, Cl-T, V-dss, and AUC were 0.62 h, 27.57 h, 38.78 h, 2.72 ml/h/kg, 105.26 ml/kg, and 515.12 h*mu g/ml, respectively. Carprofen at a single dose of 4 mg/kg showed prolonged t(1/2el) and MRT, and increased V-dss. On day 5 after the repeated administration of the 1.4 mg/kg dose, the t(1/2 alpha), t(1/2el), MRT, Cl-T, V-dss, and AUC were 1.12 h, 57.48 h, 82.18 h, 0.55 ml/h/kg, 45.43 ml/kg, and 2532 h*mu g/ml, respectively. Carprofen at a repeated dose of 4 mg/kg showed increased Cl-T and V-dss and decreased AUC/dose. Although the long t(1/2 lambda z) in single and multiple IV dose studies suggest the possibility of its effective use, the IV route may not be practical in sheep. Therefore, oral and subcutaneous routes of carprofen in sheep would be more valuable in clinical settings.
dc.description.sponsorshipCoordination of Scientific Research Projects, University of Kastamonu
dc.description.sponsorshipThe Coordination of Scientific Research Projects, University of Kastamonu
dc.identifier.doi10.1111/jvp.13079
dc.identifier.endpage487
dc.identifier.issn0140-7783
dc.identifier.issn1365-2885
dc.identifier.issue5
dc.identifier.pmid35748159
dc.identifier.scopus2-s2.0-85132550987
dc.identifier.scopusqualityQ1
dc.identifier.startpage481
dc.identifier.urihttps://doi.org/10.1111/jvp.13079
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7148
dc.identifier.volume45
dc.identifier.wosWOS:000815023500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectcarprofen
dc.subjectintravenous
dc.subjectmultiple doses
dc.subjectpharmacokinetics
dc.subjectsheep
dc.titlePharmacokinetics of carprofen following single and repeated intravenous administrations of different doses in sheep
dc.typeArticle

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