Effect of supportive therapy on the pharmacokinetics of intravenous marbofloxacin in endotoxemic sheep

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dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.authoridCoskun, Devran/0000-0003-1151-1861
dc.contributor.authorCoskun, Devran
dc.contributor.authorCorum, Orhan
dc.contributor.authorYazar, Enver
dc.date.accessioned2024-12-24T19:29:34Z
dc.date.available2024-12-24T19:29:34Z
dc.date.issued2020
dc.departmentSiirt Üniversitesi
dc.description.abstractThe purpose of this study was to determine the influences of supportive therapy (ST) on the pharmacokinetics (PK) of marbofloxacin in lipopolysaccharide (LPS)-induced endotoxemic sheep. Furthermore, minimum inhibitory concentration (MIC) of marbofloxacin against Escherichia coli, Mannheimia haemolytica, Pasteurella multocida, Klebsiella pneumoniae, Salmonella spp., and Staphylococcus aureus was determined. The study was performed using a three-period cross PK design following a 15-day washout period. In the first period, marbofloxacin (10 mg/kg) was administered by an intravenous (IV) injection. In the second and third periods, marbofloxacin was co-administered with ST (lactated ringer + 5% dextrose + 0.45% sodium chloride, IV, 20 ml/kg, dexamethasone 0.5 mg/kg, SC) and ST + LPS (E. coli O55:B5, 10 mu g/kg), respectively. Plasma marbofloxacin concentration was measured using HPLC-UV. Following IV administration of marbofloxacin alone, the t1/2 lambda z, AUC(0-infinity), Cl-T, and V-dss were 2.87 hr, 34.73 hr x mu g/ml, 0.29 L hr(-1) kg(-1), and 0.87 L/kg, respectively. While no change was found in the MBX + ST group in terms of the PK parameters of marbofloxacin, it was determined that the Cl-T of marbofloxacin decreased, AUC(0-infinity) increased, and t1/2 lambda z and MRT prolonged in the MBX + ST + LPS group. MIC values of marbofloxacin were 0.031 to >16 mu g/ml for E. coli, 0.016 to >16 mu g/ml for M. haemolytica, 0.016-1 mu g/ml for P. multocida, 0.016-0.25 mu g/ml for K. pneumoniae, 0.031-0.063 mu g/ml for Salmonella spp., and 0.031-1 mu g/ml for S. aureus. The study results show the necessity to make a dose adjustment of marbofloxacin following concomitant administration of ST in endotoxemic sheep. Also, the PK and pharmacodynamic effect of marbofloxacin needs to be determined in naturally infected septicemic sheep following concomitant administration of single and ST.
dc.description.sponsorshipOYP [2017-OYP-008] Funding Source: Medline
dc.identifier.doi10.1111/jvp.12849
dc.identifier.endpage296
dc.identifier.issn0140-7783
dc.identifier.issn1365-2885
dc.identifier.issue3
dc.identifier.pmid32133667
dc.identifier.scopus2-s2.0-85082310044
dc.identifier.scopusqualityQ1
dc.identifier.startpage288
dc.identifier.urihttps://doi.org/10.1111/jvp.12849
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7145
dc.identifier.volume43
dc.identifier.wosWOS:000528051100005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectendotoxemia
dc.subjectmarbofloxacin
dc.subjectpharmacokinetics
dc.subjectsheep
dc.subjectsupportive therapy
dc.titleEffect of supportive therapy on the pharmacokinetics of intravenous marbofloxacin in endotoxemic sheep
dc.typeArticle

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