Design of a new porphyrin-based compound and investigation of its photosensitive properties for antibacterial photodynamic therapy

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dc.contributor.authorKurtar, Seda Nur Kertmen
dc.contributor.authorKertmen, Metin
dc.contributor.authorKose, Muhammet
dc.date.accessioned2024-12-24T19:27:44Z
dc.date.available2024-12-24T19:27:44Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractConsidering the increasing number of pathogens resistant to commonly used antibiotics as well as antiseptics, there is an urgent need for antimicrobial approaches that can effectively inactivate pathogens without the risk of establishing resistance. An alternative approach in this context is antibacterial photodynamic therapy (APDT). APDT is a process that involves bacterial cell death using appropriate wavelength light energy and photosensitizer and causes the production of reactive oxygen species inside or outside the microbial cell depending on the penetration of light energy. In our study, a new porphyrin compound 4,4 '-methylenebis(2-((E)-((4-(10,15,20triphenylporphyrin-5-yl)phenyl)imino)methyl)phenol) (SP) was designed and synthesized as photosensitizer and its structure was clarified by NMR (13C and 1H) and mass determination method. Photophysical and photochemical properties were examined in detail using different methods. Singlet oxygen quantum yields were obtained as 0.48 and 0.59 by direct and indirect methods, respectively. Antibacterial activity studies have been conducted within the scope of biological activity and promising results have been obtained under LED light (500-700 nm, 265 V, 1500 LM), contributing to the antibacterial photodynamic therapy literature.
dc.description.sponsorshipKahramanmaras Sutcu Imam University [2019/5-12D]
dc.description.sponsorshipAuthors are grateful to Kahramanmaras Sutcu Imam University for the financial support for this work (Project number: 2019/5-12D).
dc.identifier.doi10.1016/j.saa.2024.124529
dc.identifier.issn1386-1425
dc.identifier.issn1873-3557
dc.identifier.pmid38824758
dc.identifier.scopus2-s2.0-85194712792
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.saa.2024.124529
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6770
dc.identifier.volume319
dc.identifier.wosWOS:001249563600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofSpectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectPhotodynamic therapy
dc.subjectSinglet oxygen
dc.subjectFluorescence
dc.subjectQuantum yield
dc.subjectAntibacterial
dc.titleDesign of a new porphyrin-based compound and investigation of its photosensitive properties for antibacterial photodynamic therapy
dc.typeArticle

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