Investigation of gastrointestinal injury-related biomarkers in dairy cattle with displaced abomasum

Basit Öğe Kaydı
dc.authoridDURGUT, MURAT KAAN/0000-0002-4582-8536
dc.authoridERTURK, ALPER/0000-0002-4271-7953
dc.authoridSULU, KADIR/0000-0002-7246-8185
dc.authoridALKAN, Fahrettin/0000-0001-9637-1903
dc.authoridGulersoy, Erdem/0000-0001-8511-0150
dc.authoridNASERI, AMIR/0000-0001-9140-5879
dc.contributor.authorIder, Merve
dc.contributor.authorYildiz, Ramazan
dc.contributor.authorNaseri, Amir
dc.contributor.authorGulersoy, Erdem
dc.contributor.authorAlkan, Fahrettin
dc.contributor.authorOk, Mahmut
dc.contributor.authorErturk, Alper
dc.date.accessioned2024-12-24T19:24:22Z
dc.date.available2024-12-24T19:24:22Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractBackgroundDisplaced abomasum (DA) is one of the most important metabolic disorders of dairy cattle. In DA, ischaemic damage may occur as a result of impaired perfusion due to abomasal displacement, which may result in gastrointestinal mucosal damage.ObjectiveInvestigation of gastrointestinal tissue damage in cattle with right displacement of the abomasum (RDA) and left displacement of the abomasum (LDA) using intestinal-related biomarkers.MethodsForty-eight DA (24 LDA, 24 RDA) and 15 healthy Holstein dairy cows were enrolled between March 2021 and July 2022. Serum biomarkers including gamma-enteric smooth muscle actin (ACTG-2), liver-fatty acid binding proteins (L-FABP), platelet activating factor (PAF), trefoil factor-3 (TFF-3), leptin, claudin-3 and interleukin-8 (IL-8) concentrations were measured from venous blood samples.ResultsL-FABP concentrations in the LDA group and TFF-3 concentrations in the RDA group were lower than in the control group. The leptin concentration of the RDA group was higher than that of the other groups. There was a negative correlation between lactate, leptin and IL-8 concentrations. There was a negative correlation between lactate and TFF-3, whereas leptin and lactate were positively correlated. Leptin was the more reliable biomarker for discriminating between RDA and LDA cases.ConclusionChanges in serum L-FABP, TFF-3 and leptin concentrations in cattle with DA may reflect acute intestinal injury and the subsequent repair phase. However, these biomarkers had poor diagnostic performance in discriminating between healthy and cattle with DA, while leptin emerged as the most useful marker in differentiating LDA from RDA cases. In this study, intestinal injury-related biomarkers were evaluated in serum samples from dairy cows with displaced abomasum (DA). Serum fatty acid binding proteins, trefoil factor-3 and leptin concentrations in cattle with DA indicate that intestinal damage develops in DA cases and the repair phase is activated against this damage.image
dc.identifier.doi10.1002/vms3.1292
dc.identifier.endpage2900
dc.identifier.issn2053-1095
dc.identifier.issue6
dc.identifier.pmid37776262
dc.identifier.scopus2-s2.0-85173482857
dc.identifier.scopusqualityQ1
dc.identifier.startpage2893
dc.identifier.urihttps://doi.org/10.1002/vms3.1292
dc.identifier.urihttps://hdl.handle.net/20.500.12604/5942
dc.identifier.volume9
dc.identifier.wosWOS:001075385700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofVeterinary Medicine and Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectcattle
dc.subjectleft displacement of abomasum
dc.subjectleptin
dc.subjectliver-fatty acid binding proteins
dc.subjectright displacement of abomasum
dc.subjecttrefoil factor-3
dc.titleInvestigation of gastrointestinal injury-related biomarkers in dairy cattle with displaced abomasum
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu