CITED1 expression in odontogenic cysts

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dc.authoridOzalp, Zeki/0000-0001-7168-7477
dc.authoridTas, Fatih/0000-0001-9817-4241
dc.authoridYulek, Ozden/0000-0001-7557-0268
dc.contributor.authorAsir, Firat
dc.contributor.authorOzalp, Zeki
dc.contributor.authorYulek, oezden Uctu
dc.contributor.authorErdemci, Fikri
dc.contributor.authorKorak, Tugcan
dc.contributor.authorTas, Fatih
dc.date.accessioned2024-12-24T19:29:53Z
dc.date.available2024-12-24T19:29:53Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractBackgroundOriginating from odontogenic tissue, Odontogenic cysts are pathological cavities lined with epithelial cells and surrounded by fibrous connective tissue. This study investigated expression of CITED1 protein in different types of odontogenic cysts.Material and method40 keratocysts, 40 radicular cysts, and 40 dentigerous cysts were excised and processed for routine paraffin wax embedding protocol. Macroscopic and panoramic radiographies images were used for diagnosis. Demographical properties and dental parameters were recorded. Cystic tissues were stained with hematoxylin-eosin dye and CITED1 antibody. Semi-quantitative analysis was performed for immune staining. The protein-protein interaction network, hub gene detection and KEGG analysis were conducted using Cytoscape software.ResultOdontogenic keratocysts was imaged with 6-8 layered epithelial cells and fibrous cyst walls with inflammatory cells. Radicular cysts had stratified squamous epithelium with varying thickness, ciliated cells, and Rushton hyaline bodies. Dentigerous cysts presented hyperplastic non-keratinized epithelium, fibrous tissue, rete ridges, and inflammatory cells. CITED1 immunoexpression was highest in odontogenic keratocysts, followed by radicular cysts, and lowest in dentigerous cysts. Nuclear and cytoplasmic CITED1 expression was significantly elevated in odontogenic keratocysts compared to radicular and dentigerous cysts. The top five targets of CITED1 were identified, primarily showing enrichment in hormone and cancer related pathways.ConclusionsPositive CITED1 expression in all three types of odontogenic cysts suggest a potential role for CITED1 in the pathogenesis of odontogenic cysts, particularly in keratocysts. Further investigations are needed to elucidate the exact mechanisms underlying the differential expression of CITED1 and its implications for the development and progression of odontogenic cysts.
dc.identifier.doi10.1186/s12903-024-04413-4
dc.identifier.issn1472-6831
dc.identifier.issue1
dc.identifier.pmid38997708
dc.identifier.scopus2-s2.0-85198458975
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/s12903-024-04413-4
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7297
dc.identifier.volume24
dc.identifier.wosWOS:001266855300002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmc
dc.relation.ispartofBmc Oral Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectOdontogenic cyst
dc.subjectKeratocyst
dc.subjectRadicular cyst
dc.subjectDentigerous cyst
dc.subjectCITED1
dc.titleCITED1 expression in odontogenic cysts
dc.typeArticle

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