Antioxidant, Antiglaucoma, Anticholinergic, and Antidiabetic Effects of Kiwifruit (Actinidia deliciosa) Oil: Metabolite Profile Analysis Using LC-HR/MS, GC/MS and GC-FID

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dc.authoridGoren, Ahmet C/0000-0002-5470-130X
dc.authoridbingol, zeynebe/0000-0003-3373-779X
dc.authoridUc, Eda Mehtap/0000-0002-9259-5704
dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridKARAGECILI, HASAN/0000-0001-6912-3998
dc.contributor.authorOzden, Eda Mehtap
dc.contributor.authorBingol, Zeynebe
dc.contributor.authorMutlu, Muzaffer
dc.contributor.authorKaragecili, Hasan
dc.contributor.authorKoksal, Ekrem
dc.contributor.authorGoren, Ahmet C.
dc.contributor.authorAlwasel, Saleh H.
dc.date.accessioned2024-12-24T19:33:42Z
dc.date.available2024-12-24T19:33:42Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractDetermining the antioxidant abilities and enzyme inhibition profiles of medicinally important plants and their oils is of great importance for a healthy life and the treatment of some common global diseases. Kiwifruit (Actinidia deliciosa) oil was examined and researched using several bioanalytical methods comprehensively for the first time in this research to determine its antioxidant, antiglaucoma, antidiabetic and anti-Alzheimer's capabilities. Additionally, the kiwifruit oil inhibitory effects on acetylcholinesterase (AChE), carbonic anhydrase II (CA II), and alpha-amylase, which are linked to a number of metabolic illnesses, were established. Furthermore, LC-HRMS analysis was used to assess the phenolic content of kiwifruit oil. It came to light that kiwifruit oil contained 26 different phenolic compounds. According to the LC-HRMS findings, kiwifruit oil is abundant in apigenin (74.24 mg/L oil), epigallocatechin (12.89 mg/L oil), caryophyllene oxide (12.89 mg/L oil), and luteolin (5.49 mg/L oil). In addition, GC-MS and GC-FID studies were used to ascertain the quantity and chemical composition of the essential oils contained in kiwifruit oil. Squalene (53.04%), linoleoyl chloride (20.28%), linoleic acid (2.67%), and palmitic acid (1.54%) were the most abundant compounds in kiwifruit oil. For radical scavenging activities of kiwifruit oil, 1,1-diphenyl-2-picryl-hydrazil (DPPH center dot) and 2,2 '-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS(center dot+)) radicals scavenging techniques were examined. These methods effectively demonstrated the potent radical scavenging properties of kiwifruit oil (IC50: 48.55 mu g/mL for DPPH center dot, and IC50: 77.00 mu g/mL for ABTS(center dot+) scavenging). Also, for reducing capabilities, iron (Fe3+), copper (Cu2+), and Fe3+-2,4,6-tri(2-pyridyl)-S-triazine (TPTZ) reducing abilities were studied. Moreover, kiwifruit oil showed a considerable inhibition effect towards hCA II (IC50: 505.83 mu g/mL), AChE (IC50: 12.80 mu g/mL), and alpha-amylase (IC50: 421.02 mu g/mL). The results revealed that the use of kiwifruit oil in a pharmaceutical procedure has very important effects due to its antioxidant, anti-Alzheimer, antidiabetic, and antiglaucoma effects.
dc.description.sponsorshipKing Saud University, Saudi Arabia [RSP-2023/59]
dc.description.sponsorshipI. Gulcin would like to extend his sincere appreciation to the Turkish Academy of Sciences (TUBA). S. H. Alwasel would like to extend his sincere appreciation to the Researchers Supporting Project (RSP-2023/59), King Saud University, Saudi Arabia.
dc.identifier.doi10.3390/life13091939
dc.identifier.issn2075-1729
dc.identifier.issue9
dc.identifier.pmid37763342
dc.identifier.scopus2-s2.0-85172454616
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/life13091939
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8228
dc.identifier.volume13
dc.identifier.wosWOS:001076599400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofLife-Basel
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectActinidia deliciosa
dc.subjectpolyphenol
dc.subjectkiwifruit oil
dc.subjectantioxidant activity
dc.subjectLC-HRMS
dc.subjectGC-MS
dc.subjectenzyme inhibition
dc.titleAntioxidant, Antiglaucoma, Anticholinergic, and Antidiabetic Effects of Kiwifruit (Actinidia deliciosa) Oil: Metabolite Profile Analysis Using LC-HR/MS, GC/MS and GC-FID
dc.typeArticle

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