Synthesis and carbonic anhydrase inhibitory properties of tetrazole- and oxadiazole substituted 1,4-dihydropyrimidinone compounds

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dc.authoridKAYA, Mustafa Oguzhan/0000-0002-8592-1567
dc.authoridGencer, Nahit/0000-0001-7092-8857
dc.authoridARSLAN, Mustafa/0000-0003-0796-4374
dc.contributor.authorCelik, Fatma
dc.contributor.authorArslan, Mustafa
dc.contributor.authorKaya, Mustafa Oguzhan
dc.contributor.authorYavuz, Emre
dc.contributor.authorGencer, Nahit
dc.contributor.authorArslan, Oktay
dc.date.accessioned2024-12-24T19:30:59Z
dc.date.available2024-12-24T19:30:59Z
dc.date.issued2014
dc.departmentSiirt Üniversitesi
dc.description.abstractA new series of tetrazole-, oxadiazole-and cyanosubstituted 1,4-dihydropyrimidinone compounds were synthesized, and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA) I were evaluated. 4-Cyanophenyl-1,4- dihydropyrimidinone compounds were prepared with 1,3-diketone, cyanobenzaldehyde and urea. The compounds were reacted with sodium azide and then with anhydride to get the final products. The results showed that all the synthesized compounds inhibited the CA isoenzyme activity. The compound 4-(1,7,7-trimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinazoline- 4-yl) benzonitrile 6c (IC50 = 0.0547 mM) has the most inhibitory effect.
dc.description.sponsorshipResearch Fund of the Sakarya University [2010-02-04-013]
dc.description.sponsorshipThis work was supported by Research Fund of the Sakarya University. Project Number: 2010-02-04-013.
dc.identifier.doi10.3109/21691401.2013.769448
dc.identifier.endpage62
dc.identifier.issn2169-1401
dc.identifier.issn2169-141X
dc.identifier.issue1
dc.identifier.pmid23419142
dc.identifier.scopus2-s2.0-84892699256
dc.identifier.scopusqualityQ1
dc.identifier.startpage58
dc.identifier.urihttps://doi.org/10.3109/21691401.2013.769448
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7759
dc.identifier.volume42
dc.identifier.wosWOS:000329845100008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInforma Healthcare
dc.relation.ispartofArtificial Cells Nanomedicine and Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectcarbonic anhydrase
dc.subjectdihydropyrimidinone
dc.subjectenzyme
dc.subjectinhibitor
dc.subjectoxadiazole
dc.subjecttetrazole
dc.titleSynthesis and carbonic anhydrase inhibitory properties of tetrazole- and oxadiazole substituted 1,4-dihydropyrimidinone compounds
dc.typeArticle

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