Ovine PAPPA2 gene coding variants are linked to decreased fecal egg shedding in native Turkish sheep naturally infected with gastrointestinal nematodes

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dc.authoridYILMAZ, ONUR/0000-0002-5658-8558
dc.authoridBay, Veysel/0000-0002-9339-4840
dc.contributor.authorYaman, Yalcin
dc.contributor.authorBay, Veysel
dc.contributor.authorSevim, Semih
dc.contributor.authorAymaz, Ramazan
dc.contributor.authorKeles, Murat
dc.contributor.authorOnaldi, A. Taner
dc.contributor.authorOzuicli, Mehmet
dc.date.accessioned2024-12-24T19:24:50Z
dc.date.available2024-12-24T19:24:50Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractIn this study, the association between PAPPA2 coding variants and gastrointestinal (GI) nematode fecal egg count (FEC) score in adult Turkish sheep was investigated. For this purpose, the FEC score was determined in adult sheep from six breeds: Karacabey Merino (n = 137), Kivircik (n = 116), Cine capari (n = 109), Karakacan (n = 102), Imroz (n = 73), and Chios (n = 50). Sheep were classified as shedders or non-shedders within breeds and flocks. The first group was the fecal egg shedders (> 50 per gram of feces), and the second group was the no fecal egg shedders (<= 50 per gram of feces). The exon 1, exon 2, exon 5, exon 7, and a part of 5 ' UTR of the ovine PAPPA2 gene were genotyped by Sanger sequencing of these two groups. Fourteen synonymous and three non-synonymous single-nucleotide polymorphisms (SNPs) were found. The non-synonymous SNPs, D109N, D391H, and L409R variants, are reported for the first time. Two haplotype blocks were constructed on exon 2 and exon 7. The specific haplotype, C(391)G(424)G(449)T(473)C(515)A(542) on the exon 2 that carries the 391H variant, was tested against four other common haplotypes. Our results indicate that C(391)G(424)G(449)T(473)C(515)A(542) haplotype was significantly associated with fecal egg shedding status in adult Turkish sheep (p-value, 0.044).
dc.description.sponsorshipepublic of Turkey Ministry of Agriculture and Forestry, General Directorate of Agricultural Research and Policies [TAGEM/HAYSUED/15/A01/P02/0202]
dc.description.sponsorshipThis research has been funded by the Republic of Turkey Ministry of Agriculture and Forestry, General Directorate of Agricultural Research and Policies (Project number: TAGEM/HAYSUED/15/A01/P02/02-02).
dc.identifier.doi10.1007/s11250-023-03612-5
dc.identifier.issn0049-4747
dc.identifier.issn1573-7438
dc.identifier.issue3
dc.identifier.pmid37130990
dc.identifier.scopus2-s2.0-85158063980
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s11250-023-03612-5
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6135
dc.identifier.volume55
dc.identifier.wosWOS:000984013200003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofTropical Animal Health and Production
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectSheep
dc.subjectPAPPA2
dc.subjectGastrointestinal nematodes
dc.subjectGenetic resistance
dc.subjectsusceptibility
dc.titleOvine PAPPA2 gene coding variants are linked to decreased fecal egg shedding in native Turkish sheep naturally infected with gastrointestinal nematodes
dc.typeArticle

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