Genome-wide discovery of underlying genetic factors associated with fresh and frozen-thawed semen traits in composite ram breeds exhibiting different cryotolerance.

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dc.contributor.authorBülbül, Bülent
dc.contributor.authorDoğan, Şükrü
dc.contributor.authorDayanikli, Cemal
dc.contributor.authorKirbaş, Mesut
dc.contributor.authorŞengül, Ebru
dc.contributor.authorKal, Yavuz
dc.contributor.authorYaman, Yalçın
dc.date.accessioned2025-01-15T07:24:57Z
dc.date.available2025-01-15T07:24:57Z
dc.date.issued2025-01-08
dc.departmentFakülteler, Veteriner Fakültesi, Zootekni ve Hayvan Besleme Bölümü
dc.description.abstractFewer studies investigate the effects of underlying genetic factors related to semen characteristics, significantly affecting sheep farm profitability. This study aimed to identify single nucleotide polymorphisms (SNP) and genomic regions associated with fresh and frozen-thawed semen traits in rams with low (Hasak) and high (Hasmer) cryotolerance. Semen collected from 11 (5 Hasak with low and 6 Hasmer with high cryotolerance) rams cryopreserved in 0.25 ml straws in the breeding season. Quality characteristics were determined in fresh, equilibrated, and frozen-thawed semen. A Genome-Wide Association Study (GWAS) was conducted to unveil the genetic structure that might be attributed to cryotolerance in low and high cryotoleranced rams. Fresh (regarding total and progressive motility) and equilibrated semen quality were similar in Hasak and Hasmer rams (p > 0.6). However, the freeze-thawing process had a more pronounced negative effect on ram semen traits in Hasak than in Hasmer (p < 0.05). GWAS revealed 27 SNPs correlated with post-thaw semen parameters. Moreover, network analyses revealed pathways related to sperm ion channels and their activities, providing insights into the intricate molecular mechanisms underlying sperm physiology and emphasizing their role in potentially impacting sperm cryotolerance. The functional significance of detected SNPs and the associated pathways require further exploration.
dc.identifier.citationBÜLBÜL, B., DOĞAN, Ş., DAYANIKLI, C., KIRBAŞ, M., SENGÜL, E., Yavuz, K. A. L., & Yaman, Y. (2024). Genome-wide discovery of underlying genetic factors associated with fresh and frozen-thawed semen traits in composite ram breeds exhibiting different cryosensitivity.
dc.identifier.doi10.1016/j.cryobiol.2025.105197
dc.identifier.other39793643
dc.identifier.pmidPMID: 39793643
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.cryobiol.2025.105197
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8454
dc.indekslendigikaynakPubMed
dc.institutionauthorYaman, Yalçın
dc.institutionauthorid0000-0003-2705-2831
dc.language.isoen
dc.publisherElsevier BV
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGenome-wide association study
dc.subjectcryotolerance
dc.subjectram semen
dc.titleGenome-wide discovery of underlying genetic factors associated with fresh and frozen-thawed semen traits in composite ram breeds exhibiting different cryotolerance.

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