The effect of astaxanthin and cadmium on rat erythrocyte G6PD, 6PGD, GR, and TrxR enzymes activities in vivo and on rat erythrocyte 6PGD enzyme activity in vitro

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dc.authoridbengu, aydin sukru/0000-0002-7635-4855
dc.authoridEkin, Suat/0000-0002-6502-5028
dc.contributor.authorAkkoyun, Mahire Bayramoglu
dc.contributor.authorBengu, A. Sukru
dc.contributor.authorTemel, Yusuf
dc.contributor.authorAkkoyun, H. Turan
dc.contributor.authorEkin, Suat
dc.contributor.authorCiftci, Mehmet
dc.date.accessioned2024-12-24T19:24:11Z
dc.date.available2024-12-24T19:24:11Z
dc.date.issued2018
dc.departmentSiirt Üniversitesi
dc.description.abstractIn this study, the effects of astaxanthin (AST) that belongs to carotenoid family and cadmium (Cd), which is an important heavy metal, on rat erythrocyte G6PD, 6PGD, GR, and TrxR enzyme activities in vivo and on rat erythrocyte 6PGD enzyme activity in vitro were studied. In in vitro studies, 6PGD enzyme was purified from rat erythrocytes with 2',5'-ADP Sepharose4B affinity chromatography. Results showed inhibition of enzyme by Cd at IC50; 346.5 mu M value and increase of 6PGD enzyme activity by AST. In vivo studies showed an increase in G6PD, 6PGD. and GR enzyme activities (P > 0.05) and no chance in TrxR enzyme activity by AST. Cd ion inhibited GbPD, 6PGD, and GR enzyme activities (P < 0.05) and also decreased TrxR enzyme activity (P > 0.05). AST + Cd group G6PD enzyme activity was statistically low compared with control group (P < 0.05). 6PGD and TrxR enzyme activities decreased without statistical significance (P > 0.05); however, GR enzyme activity increased statistically significantly (P < 0.05).
dc.identifier.doi10.1002/jbt.22170
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue8
dc.identifier.pmid29975440
dc.identifier.scopus2-s2.0-85050886317
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/jbt.22170
dc.identifier.urihttps://hdl.handle.net/20.500.12604/5885
dc.identifier.volume32
dc.identifier.wosWOS:000442988900005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Biochemical and Molecular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subject6PGD
dc.subjectastaxanthin
dc.subjectcadmium
dc.subjectG6PD
dc.subjectGR
dc.subjectTrxR
dc.titleThe effect of astaxanthin and cadmium on rat erythrocyte G6PD, 6PGD, GR, and TrxR enzymes activities in vivo and on rat erythrocyte 6PGD enzyme activity in vitro
dc.typeArticle

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