Effect of ketoprofen on intravenous pharmacokinetics of ganciclovir in chukar partridges (Alectoris chukar)

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dc.authoridElmas, Prof. Dr., Muammer/0000-0001-9059-7151
dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.authoridZhunushova, Aidai/0000-0002-5331-7648
dc.authoridCoskun, Devran/0000-0003-1151-1861
dc.authoridAtik, Orkun/0000-0003-2411-7492
dc.authoridUney, Kamil/0000-0002-8674-4873
dc.contributor.authorCorum, Orhan
dc.contributor.authorUney, Kamil
dc.contributor.authorCorum, Duygu Durna
dc.contributor.authorAtik, Orkun
dc.contributor.authorCoskun, Devran
dc.contributor.authorZhunushova, Aidai
dc.contributor.authorElmas, Muammer
dc.date.accessioned2024-12-24T19:29:35Z
dc.date.available2024-12-24T19:29:35Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractThe aim of the study was to determine the effect of ketoprofen (2 mg/kg) on the intravenous pharmacokinetics of ganciclovir (10 mg/kg) in chukar partridges (Alectoris chukar). Eight clinically healthy partridges were used in the study. The study was performed in two periods using a cross-over design following a 15-day drug washout period. Plasma concentrations of ganciclovir were determined using the high-pressure liquid chromatography-ultraviolet detector and analyzed by non-compartmental analysis. The elimination half-life (t(1/2 lambda z)), area under the concentration-time curve (AUC(0-infinity)), total body clearance, and volume of distribution at steady state of ganciclovir were 1.63 h, 33.22 h*mu g/ml, 0.30 L/h/kg, and 0.53 L/kg, respectively. Ketoprofen administration increased the t(1/2 lambda z) and AUC(0-infinity) of ganciclovir by 78% and 108%, respectively, and while decreased Cl-T by 53%. The increased plasma concentration and prolonged elimination half-life of ganciclovir caused by ketoprofen may result in the prolonged duration of action and therapeutic effect of ganciclovir. However, the concomitant use requires determination of the pharmacokinetics of ketoprofen and the safety of both drugs.
dc.description.sponsorshipCoordination of Scientific Research Projects, University of Selcuk, Turkey [19401073]
dc.description.sponsorshipThe Coordination of Scientific Research Projects, University of Selcuk, Turkey, Grant/Award Number: 19401073
dc.identifier.doi10.1111/jvp.13027
dc.identifier.endpage132
dc.identifier.issn0140-7783
dc.identifier.issn1365-2885
dc.identifier.issue1
dc.identifier.pmid34719792
dc.identifier.scopus2-s2.0-85118292889
dc.identifier.scopusqualityQ1
dc.identifier.startpage126
dc.identifier.urihttps://doi.org/10.1111/jvp.13027
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7147
dc.identifier.volume45
dc.identifier.wosWOS:000713031600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectchukar partridges
dc.subjectganciclovir
dc.subjectketoprofen
dc.subjectpharmacokinetics
dc.titleEffect of ketoprofen on intravenous pharmacokinetics of ganciclovir in chukar partridges (Alectoris chukar)
dc.typeArticle

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