Assessment of lipocalin-1, resistin, cathepsin-D, neurokinin A, agmatine, NGF, and BDNF serum levels in children with Autism Spectrum Disorder

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dc.contributor.authorVeysel Tahiroğlu
dc.contributor.authorCüneyt Cağlayan
dc.contributor.authorAyşe Gizem Güleç
dc.contributor.authorSinem Yavuz Öztürk
dc.contributor.authorHasan Karageçili
dc.contributor.authorTahir Çağlar
dc.date.accessioned2025-05-05T11:34:04Z
dc.date.available2025-05-05T11:34:04Z
dc.date.issued2025-04-21
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümü
dc.description.abstractAutism Spectrum Disorder (ASD) is a neurological and developmental disorder that affects all aspects of social communication, with stereotypical and limited interest and atypical responses to sensory stimuli. There isn't a reliable lab test that can help clinicians diagnose ASD. This study aimed to examine serum lipocalin-1, resistin, cathepsin-D, neurokinin A, agmatinase, brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and glial fibrillary acidic protein (GFAP) levels in children with ASD. The study had 40 matched control subjects and 39 ASD sufferers in total. The diagnosis was made by medical professionals using the Gilliam Autistic Disorder Rating Scale-2-TV (GOBDÖ-2-TV), Denver Developmental Screening Test, and Porteus Intelligence Tests. Compared to the control group, serum levels of lipocalin-1, resistin, cathepsin-D, agmatinase, BDNF, and NGF were found to be high and GFAP levels were low in children having ASD. B12 and magnesium levels were significantly lower in the ASD group than in the control group, while sodium and chloride levels were higher in the ASD group (p<0.05). The aforementioned parameters may be involved in the pathophysiology of ASD, as evidenced by the fact that their values were greater in children with ASD than in controls. Additionally, evaluation of some routinely measured biochemical parameters may suggest that nutritional and electrolyte balance may differ in individuals with ASD.
dc.identifier.citationTahiroğlu, V., Cağlayan, C., Güleç, A. G., Yavuz Öztürk, S., Karageçili, H., & Çağlar, T. (2025). Assessment of lipocalin-1, resistin, cathepsin-D, neurokinin A, agmatine, NGF, and BDNF serum levels in children with Autism Spectrum Disorder. Turkish Journal of Biochemistry, (0).
dc.identifier.doi10.1515/tjb-2024-0394
dc.identifier.issn1303-829X
dc.identifier.scopus2-s2.0-105003320615
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.1515/tjb-2024-0394
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8640
dc.identifier.wos001470307300001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorKarageçili, Hasan
dc.institutionauthorid0000-0001-6912-3998
dc.publisherWalter de Gruyter GmbH
dc.relation.ispartofTurkish Journal of Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAutism Spectrum Disorder
dc.subjectBDNF
dc.subjectELISA
dc.subjectGFAP
dc.subjectresistin
dc.titleAssessment of lipocalin-1, resistin, cathepsin-D, neurokinin A, agmatine, NGF, and BDNF serum levels in children with Autism Spectrum Disorder
dc.typejournal-article

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