Potential therapeutic effects of silymarin and silymarin-loaded solid lipid nanoparticles on experimental kidney damage in BALB/c mice: biochemical and histopathological evaluation

Basit Öğe Kaydı
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorAyhanci, Adnan
dc.contributor.authorKutlu, Hatice Mehtap
dc.contributor.authorMusmul, Ahmet
dc.date.accessioned2017-05-17T08:40:42Z
dc.date.available2017-05-17T08:40:42Z
dc.date.issued2016-06-21
dc.departmentBelirleneceken_US
dc.description.abstractSilymarin (Sm) is widely used in treating diseases that affect organs such as the liver, kidney, and gallbladder thanks to its antioxidative, renoprotective, antihepatotoxic, and anticarcinogenic properties. However, this substance is poorly solved in water and tends to decompose in the intestine, its bioavailability decreasing before it can show real effect. With these limitations in mind, the present study aims to enhance the poor bioavailability of Sm by forming Sm-loaded solid lipid nanoparticles (Sm-SLNs) using the hot homogenization method. A characterization process was undertaken to determine possible impact of Sm on experimental kidney damage. Our biochemical and light microscopic results suggest that the group that received Sm-SLNs for the treatment of D-GalN/ TNF-?–induced experimental kidney damage showed significantly more improvement than the group that received commercially available Sm. In conclusion, Sm-loaded SLN may be a useful system for the delivery of poorly water-soluble Sm and may also provide renoprotection.en_US
dc.description.sponsorshipAnadolu University Scientific Research Project Unit (project no.: 1305F091).en_US
dc.identifier.scopus2-s2.0-84975230609
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12604/665
dc.identifier.wosWOS:000378689600010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.relation.publicationcategoryUluslararası Editör Denetimli Dergi Makalesien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKG_20241224
dc.subjectD-GalN/TNF-αen_US
dc.subjectkidney damageen_US
dc.subjectsilymarinen_US
dc.subjectsolid lipid nanoparticleen_US
dc.subjectrenoprotectivityen_US
dc.titlePotential therapeutic effects of silymarin and silymarin-loaded solid lipid nanoparticles on experimental kidney damage in BALB/c mice: biochemical and histopathological evaluationen_US
dc.typeArticleen_US

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