Sustainable Development of Chitosan/Calotropis procera-Based Hydrogels to Stimulate Formation of Granulation Tissue and Angiogenesis in Wound Healing Applications

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dc.authoridJaved, Talha/0000-0003-2986-9992
dc.authoridZahid, Muhammad/0000-0001-8407-6886
dc.authoridRehan, Zulfiqar Ahmad/0000-0001-8508-3156
dc.authoridSiuta, Dorota/0000-0002-5504-7725
dc.authoridMukhtar, Ahmed/0000-0002-8043-2668
dc.authoridShabbir, Rubab/0000-0001-8964-1389
dc.authoridSakran, Mohamed/0000-0003-2295-6874
dc.authoridEL Sabagh, Ayman/0000-0002-4241-192X
dc.authoridAdamski, Robert/0000-0002-3023-1278
dc.contributor.authorZahid, Muhammad
dc.contributor.authorLodhi, Maria
dc.contributor.authorRehan, Zulfiqar Ahmad
dc.contributor.authorTayyab, Hamna
dc.contributor.authorJaved, Talha
dc.contributor.authorShabbir, Rubab
dc.contributor.authorMukhtar, Ahmed
dc.date.accessioned2024-12-24T19:33:42Z
dc.date.available2024-12-24T19:33:42Z
dc.date.issued2021
dc.departmentSiirt Üniversitesi
dc.description.abstractThe formation of new scaffolds to enhance healing magnitude is necessarily required in biomedical applications. Granulation tissue formation is a crucial stage of wound healing in which granulation tissue grows on the surface of a wound by the formation of connective tissue and blood vessels. In the present study, porous hydrogels were synthesized using chitosan incorporating latex of the Calotropis procera plant by using a freeze-thaw cycle to stimulate the formation of granulation tissue and angiogenesis in wound healing applications. Structural analysis through Fourier transform infrared (FTIR) spectroscopy confirmed the interaction between chitosan and Calotropis procera. Latex extract containing hydrogel showed slightly higher absorption than the control during water absorption analysis. Thermogravimetric analysis showed high thermal stability of the 60:40 combination of chitosan (CS) and Calotropis procera as compared to all other treatments and controls. A fabricated scaffold application on a chick chorioallantoic membrane (CAM) showed that all hydrogels containing latex extract resulted in a significant formation of blood vessels and regeneration of cells. Overall, the formation of connective tissues and blood capillaries and healing magnitude decreased in ascending order of concentration of extract.
dc.identifier.doi10.3390/molecules26113284
dc.identifier.issn1420-3049
dc.identifier.issue11
dc.identifier.pmid34072397
dc.identifier.scopus2-s2.0-85107423241
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/molecules26113284
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8248
dc.identifier.volume26
dc.identifier.wosWOS:000660433500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjecthydrogels
dc.subjectchitosan
dc.subjectgranulation
dc.subjectwound healing
dc.subjectsustainability
dc.subjectCalotropis procera
dc.titleSustainable Development of Chitosan/Calotropis procera-Based Hydrogels to Stimulate Formation of Granulation Tissue and Angiogenesis in Wound Healing Applications
dc.typeArticle

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