Boric acid protects against cyclophosphamide-induced oxidative stress and renal damage in rats

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dc.authoridCENGIZ, Mustafa/0000-0002-6925-8371
dc.contributor.authorCengiz, Mustafa
dc.date.accessioned2024-12-24T19:30:02Z
dc.date.available2024-12-24T19:30:02Z
dc.date.issued2018
dc.departmentSiirt Üniversitesi
dc.description.abstractThe worldwide increase in the rate of cancer incidence also leads to a significant increase in the use of chemotherapeutic agents. Unfortunately, the optimal clinical usefulness of these agents is heavy restricted by a high incidence of several organ toxicity and as well reason oxidative stress and bring about changing in antioxidant status. Kidney toxicity is a side effect often encountered with cyclophosphamide (CPM) which is commonly used in most cancer chemotherapy. The present study aims on the assessment of the probable defensive efficacy of Boric acid (BA) against CPM- induced oxidative stress and renal damage in rats. Based upon our investigation results with oxidative stress markers and light microscopic findings, it can be concluded that BA significantly reduced CPM induced oxidative stress and renal damage. As far as we know, high dose (200 mg/kg) of BA are the first study on the prevention of kidney damage caused by CPM. It is thought that the renoprotective effects of BA may be due to an increase in the activity of the antioxidant protection system and also inhibition of lipid per oxidation.
dc.identifier.doi10.14715/cmb/2018.64.12.3
dc.identifier.endpage14
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue12
dc.identifier.pmid30301495
dc.identifier.scopus2-s2.0-85054776840
dc.identifier.scopusqualityQ4
dc.identifier.startpage11
dc.identifier.urihttps://doi.org/10.14715/cmb/2018.64.12.3
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7353
dc.identifier.volume64
dc.identifier.wosWOS:000449068700003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherC M B Assoc
dc.relation.ispartofCellular and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectBoric acid
dc.subjectCyclophosphamide
dc.subjectRenoprotective
dc.subjectLipid peroxidation
dc.subjectOxidative stress
dc.subjectNephrotoxicity
dc.titleBoric acid protects against cyclophosphamide-induced oxidative stress and renal damage in rats
dc.typeArticle

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