Comparative Pharmacokinetics of Intravenous Enrofloxacin in One- Six- And Twelve-Month-Old Sheep

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dc.authoridUney, Kamil/0000-0002-8674-4873
dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.authoridCoskun, Devran/0000-0003-1151-1861
dc.contributor.authorCoskun, Devran
dc.contributor.authorCorum, Orhan
dc.contributor.authorCorum, Duygu Durna
dc.contributor.authorUney, Kamil
dc.date.accessioned2024-12-24T19:30:36Z
dc.date.available2024-12-24T19:30:36Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractBackground Enrofloxacin (ENR) is a fluoroquinolone antibiotic approved for use in sheep of all ages. The body composition and metabolic capability change with age. These changes may alter the pharmacokinetics of drugs and thus their effect. Therefore, the pharmacokinetics of drugs need to be established in target-age animals. Objective To determine the pharmacokinetics of ENR and its active metabolite, ciprofloxacin (CIP), following a single intravenous administration of ENR at a dose of 10 mg/kg in different ages of sheep. Methods The study was carried out in the one-, six- and twelve-month age period of the sheep. A single dose of 10 mg/kg ENR was administered intravenously through the jugular vein to sheep in all age periods. ENR and CIP plasma concentrations were determined using HPLC-UV and analyzed using a non-compartmental method. Results ENR was detected in the plasma until 36 h in one-month-old and up to 24 h in other ages. CIP was detected in the plasma up to 24 h in all age groups. The t(1/2 lambda z) and V-dss were significantly higher in one-month-old sheep than in six and twelve-months old sheep. There was no difference in ClT and AUC values in different age groups. AUC(0-infinity CIP)/AUC(0-infinity ENR) ratios were higher in one-month-old than in six- and twelve-months sheep. Conclusion The most important pharmacokinetic changes associated with aging in sheep are decreased V-dss and t(1/2 lambda z) of ENR and the low ratio metabolizing of ENR to CIP. Pharmacokinetic/pharmacodynamic data showed that ENR after IV administration of 10 mg/kg dose provided the optimal AUC(0-24)/MIC90 ratios for E. coli, P. multocida and Mycoplasma spp. (>125) with MIC of 0.37 mu g/mL and for S. aureus (>30) with MIC of 0.5 mu g/mL in all ages of sheep.
dc.identifier.doi10.2174/0113892002278220231208072351
dc.identifier.endpage785
dc.identifier.issn1389-2002
dc.identifier.issn1875-5453
dc.identifier.issue11
dc.identifier.pmid38141187
dc.identifier.scopus2-s2.0-85181771989
dc.identifier.scopusqualityQ3
dc.identifier.startpage780
dc.identifier.urihttps://doi.org/10.2174/0113892002278220231208072351
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7603
dc.identifier.volume24
dc.identifier.wosWOS:001151259700005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Drug Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectAge-related pharmacokinetics
dc.subjectenrofloxacin
dc.subjectciprofloxacin
dc.subjectintravenous
dc.subjectsheep, metabolite
dc.titleComparative Pharmacokinetics of Intravenous Enrofloxacin in One- Six- And Twelve-Month-Old Sheep
dc.typeArticle

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