Antioxidant, Antidiabetic, Anticholinergic, and Antiglaucoma Effects of Magnofluorine

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dc.authoridKARAGECILI, HASAN/0000-0001-6912-3998
dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridGUVEN, LEYLA/0000-0002-3189-6415
dc.contributor.authorDurmaz, Lokman
dc.contributor.authorKiziltas, Hatice
dc.contributor.authorGuven, Leyla
dc.contributor.authorKaragecili, Hasan
dc.contributor.authorAlwasel, Saleh
dc.contributor.authorGulcin, Ilhami
dc.date.accessioned2024-12-24T19:33:43Z
dc.date.available2024-12-24T19:33:43Z
dc.date.issued2022
dc.departmentSiirt Üniversitesi
dc.description.abstractMagnofluorine, a secondary metabolite commonly found in various plants, has pharmacological potential; however, its antioxidant and enzyme inhibition effects have not been investigated. We investigated the antioxidant potential of Magnofluorine using bioanalytical assays with 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(center dot+)), N,N-dimethyl-p-phenylenediamine dihydrochloride (DMPD center dot+), and 1,1-diphenyl-2-picrylhydrazyl (DPPH center dot) scavenging abilities and K-3[Fe(CN)(6)] and Cu2+ reduction abilities. Further, we compared the effects of Magnofluorine and butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), alpha-Tocopherol, and Trolox as positive antioxidant controls. According to the analysis results, Magnofluorine removed 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals with an IC50 value of 10.58 mu g/mL. The IC50 values of BHA, BHT, Trolox, and alpha-Tocopherol were 10.10 mu g/mL, 25.95 mu g/mL, 7.059 mu g/mL, and 11.31 mu g/mL, respectively. Our results indicated that the DPPH center dot scavenging effect of Magnofluorine was similar to that of BHA, close to that of Trolox, and better than that of BHT and alpha-tocopherol. The inhibition effect of Magnofluorine was examined against enzymes, such as acetylcholinesterase (AChE), alpha-glycosidase, butyrylcholinesterase (BChE), and human carbonic anhydrase II (hCA II), which are linked to global disorders, such as diabetes, Alzheimer's disease (AD), and glaucoma. Magnofluorine inhibited these metabolic enzymes with Ki values of 10.251.94, 5.991.79, 25.411.10, and 30.563.36 nM, respectively. Thus, Magnofluorine, which has been proven to be an antioxidant, antidiabetic, and anticholinergic in our study, can treat glaucoma. In addition, molecular docking was performed to understand the interactions between Magnofluorine and target enzymes BChE (D: 6T9P), hCA II (A:3HS4), AChE (B:4EY7), and alpha-glycosidase (C:5NN8). The results suggest that Magnofluorine may be an important compound in the transition from natural sources to industrial applications, especially new drugs.
dc.description.sponsorshipTUBA; King Saud University's Researchers Supporting Project [RSP-2022/59]
dc.description.sponsorshipIlhami Gulcin is a member of the Turkish Academy of Sciences (TUBA). He wants to express his heartfelt gratitude to the TUBA for their financial assistance. Saleh Alwasel wishes to express his heartfelt gratitude to King Saud University's Researchers Supporting Project (RSP-2022/59).
dc.identifier.doi10.3390/molecules27185902
dc.identifier.issn1420-3049
dc.identifier.issue18
dc.identifier.pmid36144638
dc.identifier.scopus2-s2.0-85138428621
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/molecules27185902
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8249
dc.identifier.volume27
dc.identifier.wosWOS:000856734600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectMagnofluorine
dc.subjectphenolic compound
dc.subjectbutyrylcholinesterase
dc.subjectantioxidant activity
dc.subjectcarbonic anhydrase
dc.subjectacetylcholinesterase
dc.subjectalpha-glycosidase
dc.titleAntioxidant, Antidiabetic, Anticholinergic, and Antiglaucoma Effects of Magnofluorine
dc.typeArticle

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