Oxidant/Antioxidant Status, PON1 and ARES Activities, Trace Element Levels, and Histological Alterations in Sheep with Cystic Echinococcosis

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dc.authoridCELIK, Ozgur Yasar/0000-0001-6365-2688
dc.authoridKAYA, Mustafa Oguzhan/0000-0002-8592-1567
dc.contributor.authorIrak, Kivanc
dc.contributor.authorCelik, Burcak Aslan
dc.contributor.authorKarakoc, Zelal
dc.contributor.authorCelik, Ozgur Yasar
dc.contributor.authorMert, Handan
dc.contributor.authorMert, Nihat
dc.contributor.authorKaya, Mustafa Oguzhan
dc.date.accessioned2024-12-24T19:33:20Z
dc.date.available2024-12-24T19:33:20Z
dc.date.issued2018
dc.departmentSiirt Üniversitesi
dc.description.abstractBackground: Total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI), nitric oxide (NO), zinc (Zn), copper (Cu) levels, paraoxonase (PON1), arylesterase (ARES) activities, and biochemical changes were studied on sheep with cystic echinococcosis. Methods: The materials were taken from 2-3 yr old sheep slaughtered in Van Province, Turkey in 2017. Before the slaughter, blood samples were collected from the healthy sheep, while various organs of animals were examined for hydatid cysts after the slaughter. Thirty sheep were protoscolex positive, hydatic group, while 30 sheep that did not have any pathological lesions in organ examinations were accepted as the control group. TOS levels, PON1 and ARES activities, and Zn levels were determined by commercial kits, while Cu levels were determined by atomic absorption spectrophotometer. The collected data were then statistically analyzed. Results: Serum TOS and OSI levels were significantly higher in sheep with cystic echinococcosis compared to the control group (P<0.001). TAS levels (P<0.01), PON1 and ARES activities, on the other hand, were significantly higher in control group compared to the cystic echinococcosis group (P<0.001). There were no significant differences in Zn, NO and Cu levels between the groups. Conclusion: PON1 and ARES activities increased in sheep infected with cyst hydatid. The decline of antioxidant reserves in the metabolism results in excessive amounts of free radicals, along with alterations of the normal histological structure of the cystic organ and changes in trace element metabolism.
dc.description.sponsorshipScientific Research Project Directory of the University of Siirt, Siirt, Turkey [2017-SIUVET-04]
dc.description.sponsorshipThis study was supported by the Scientific Research Project Directory of the University of Siirt, Siirt, Turkey (Project No. 2017-SIUVET-04).
dc.identifier.endpage456
dc.identifier.issn1735-7020
dc.identifier.issn2008-238X
dc.identifier.issue3
dc.identifier.pmid30483337
dc.identifier.scopus2-s2.0-85054240094
dc.identifier.scopusqualityQ3
dc.identifier.startpage448
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8090
dc.identifier.volume13
dc.identifier.wosWOS:000446557500015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherIranian Scientific Society Medical Entomology
dc.relation.ispartofIranian Journal of Parasitology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectArylesterase
dc.subjectCystic echinococcosis
dc.subjectOxidative stress
dc.subjectParaoxonase 1
dc.subjectSheep
dc.subjectTrace elements
dc.titleOxidant/Antioxidant Status, PON1 and ARES Activities, Trace Element Levels, and Histological Alterations in Sheep with Cystic Echinococcosis
dc.typeArticle

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