Investigation of growth traits in Turkish Merino lambs using multi-locus GWAS approaches: Middle Anatolian Merino

Basit Öğe Kaydı
dc.contributor.authorYalçın Yaman
dc.contributor.authorŞükrü DOĞAN
dc.contributor.authorMesut KIRBAŞ
dc.contributor.authorA. Taner ÖNALDI
dc.contributor.authorYavuz KAL
dc.date.accessioned2025-01-13T08:13:02Z
dc.date.available2025-01-13T08:13:02Z
dc.date.issued2024-12-19
dc.departmentFakülteler, Veteriner Fakültesi, Zootekni ve Hayvan Besleme Bölümü
dc.description.abstractThis study explored the genetic basis of growth traits in Middle Anatolian Merino lambs using multi-locus genome-wide association study (GWAS) analyses. Descriptive statistics indicated moderate heritability (h² = 0.363) for birth weight (BW) and (h² = 0.309) for weaning weight (WW), both statistically significant (p < 0.001). Strong genetic correlations were observed between WW and BW (rG = 0.922) and WW and Kleiber ratio (KR, rG = 0.896), implying that simultaneous improvements may be possible through targeted selection. Five multi-locus methods (mrMLM, FASTmrMLM, pLARmEB, FASTmrEMMA, and ISIS EM-BLASSO) were used to identify the polygenic basis of the traits. For BW and WW, 20 and 18 significant SNPs (LOD ≥ 5) were detected, respectively, with some SNPs co-detected by multiple methods. In contrast, only 10 significant SNPs were identified for KR, all exclusively by the ISIS EM-BLASSO approach. Pathway analyses within ± 100 Kb of associated SNPs revealed genes and pathways influencing these traits, which could be leveraged in future breeding programs for enhanced growth performance. The identified SNPs, particularly those associated with BW and WW traits, could facilitate genomic selection if validated in larger and more diverse populations.
dc.identifier.citationYaman, Y., Doğan, Ş., Kirbaş, M., Önaldi, A. T., & Kal, Y. (2024). Investigation of growth traits in Turkish Merino lambs using multi-locus GWAS approaches: Middle Anatolian Merino. BMC Veterinary Research, 20(1), 567.
dc.identifier.doi10.1186/s12917-024-04428-7
dc.identifier.issn1746-6148
dc.identifier.issue1
dc.identifier.pmid39695683
dc.identifier.scopus2-s2.0-85212392456
dc.identifier.urihttps://10.1186/s12917-024-04428-7
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8435
dc.identifier.volume20
dc.identifier.wosqualityQ1
dc.institutionauthorYaman , Yalçın
dc.language.isoen
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofBMC Veterinary Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBirth weight
dc.subjectGrowth traits
dc.subjectKleiber ratio
dc.subjectMiddle Anatolian Merino
dc.subjectMulti-locus GWAS
dc.subjectWeaning weight
dc.titleInvestigation of growth traits in Turkish Merino lambs using multi-locus GWAS approaches: Middle Anatolian Merino
dc.typejournal-article
oaire.citation.issue1
oaire.citation.volume20

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
yalçım-yaman.pdf
Boyut:
1.47 MB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
2) Makale
PubMed İndeksli Yayın Koleksiyonu