Effect of High Fructose Corn Sirup on Pancreatic Ductal Adenocarcinoma Induced by Dimethyl Benzantracene (DMBA) in Rats

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dc.authoridINAN, SEVDA/0000-0001-8138-5851
dc.authoridOzcan Sinir, Gulsah/0000-0003-3954-0058
dc.authoridSUNA, Senem/0000-0002-6947-2167
dc.contributor.authorOzcan-Sinir, Gulsah
dc.contributor.authorInan, Sevda
dc.contributor.authorSuna, Senem
dc.contributor.authorTamer, Canan Ece
dc.contributor.authorAkgul, Mustafa Baris
dc.contributor.authorBagdas, Deniz
dc.contributor.authorSonmez, Gursel
dc.date.accessioned2024-12-24T19:28:04Z
dc.date.available2024-12-24T19:28:04Z
dc.date.issued2021
dc.departmentSiirt Üniversitesi
dc.description.abstractIncreased risk of pancreatic cancer may be associated with consumption of sugar containing foods. The aim of this study was to evaluate the effect of peach nectar containing high fructose corn sirup (HFCS) consumption in a pancreatic carcinogenesis rat model induced by 7,12-Dimethyl benzanthracene (DMBA). Fifty-day-old male Sprague Dawley rats were fed with peach nectar containing HFCS + chow, peach nectar containing sucrose + chow and only chow. After 8 mo, feeding period, each group was divided into two subgroups, in which the rats were implanted with DMBA and no DMBA (sham). Histologic specimens were evaluated according to the routine tissue processing protocol. The animals withad libitumaccess to pn-HFCS, pn-sucrose and chow (only) showed significant differences in chow consumption and glucose level. Necropsy and histopathologic findings showed tumor formation in the entire group treated with DMBA. Excluding one rat in chow group, which was classified as poorly differentiated type, the others were classified as moderately differentiated pancreatic ductal adenocarcinoma (PDAC). This study demonstrated that daily intake of HFCS did not increase body weight and there was no effect of peach nectar consumption on the development of PDAC induced by DMBA in rats.
dc.description.sponsorshipBursa Uludag University Scientific Research Project [UAP(Z) 2011/65]
dc.description.sponsorshipThis research was supported by Bursa Uludag University Scientific Research Project No: UAP(Z) 2011/65.
dc.identifier.doi10.1080/01635581.2020.1770811
dc.identifier.endpage349
dc.identifier.issn0163-5581
dc.identifier.issn1532-7914
dc.identifier.issue2
dc.identifier.pmid32475178
dc.identifier.scopus2-s2.0-85086577033
dc.identifier.scopusqualityQ1
dc.identifier.startpage339
dc.identifier.urihttps://doi.org/10.1080/01635581.2020.1770811
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6909
dc.identifier.volume73
dc.identifier.wosWOS:000542464600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherRoutledge Journals, Taylor & Francis Ltd
dc.relation.ispartofNutrition and Cancer-An International Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.titleEffect of High Fructose Corn Sirup on Pancreatic Ductal Adenocarcinoma Induced by Dimethyl Benzantracene (DMBA) in Rats
dc.typeArticle

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