Pharmacokinetics and Plasma Protein Binding of Flunixin in Rainbow Trout (Oncorhynchus mykiss)

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dc.authoridCoskun, Devran/0000-0003-1151-1861
dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.authoridUney, Kamil/0000-0002-8674-4873
dc.contributor.authorUney, Kamil
dc.contributor.authorCorum, Orhan
dc.contributor.authorCorum, Duygu Durna
dc.contributor.authorCoskun, Devran
dc.contributor.authorSakin, Fatih
dc.contributor.authorElmas, Muammer
dc.date.accessioned2024-12-24T19:29:35Z
dc.date.available2024-12-24T19:29:35Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractFlunixin's pharmacokinetics, bioavailability, and plasma protein binding were examined in rainbow trout. The experiment involved 252 rainbow trout (Oncorhynchus mykiss) maintained at 12 +/- 0.6 degrees C. Flunixin was administered to rainbow trout via intravascular (IV), intramuscular (IM), and oral routes at a dosage of 2.2 mg/kg. Plasma samples were collected at times 0 (control), 0.25, 0.5, 1, 2, 4, 6, 8, 10, 12, 24, 48, 72, and 96 h. High-pressure liquid chromatography-ultraviolet was employed to quantify flunixin concentrations. The elimination half-life (t(1/2 lambda z)) for flunixin was 8.37 h for IV, 8.68 h for IM, and 8.76 h for oral. The t(1/2 lambda z) was similar between administration groups. The volume of distribution at a steady state and total body clearance were 55.81 mL/kg and 6.83 mL/h/kg, respectively, after IV administration. The mean peak plasma concentration was 6.24 +/- 0.41 mu g/mL at 4 h for oral administration and 13.98 +/- 0.86 mu g/mL at 2 h for IM administration. The in vitro protein binding ratio of flunixin in rainbow trout plasma was 96.34 +/- 2.29%. The bioavailability of flunixin after oral (25.74%) administration was lower than that after IM (66.70%) administration. Thus, developing an oral pharmaceutical formulation that can be administered with feed and has high bioavailability could enhance the therapeutic effect.
dc.description.sponsorshipThe Coordination of Scientific Research Projects, University of Hatay Mustafa Kemal, Turkiye [22]; Coordination of Scientific Research Projects, University of Hatay Mustafa Kemal
dc.description.sponsorshipThis study was supported by The Coordination of Scientific Research Projects, University of Hatay Mustafa Kemal, Turkiye (Project No. 22.GAP.029).
dc.identifier.doi10.1111/jvp.13481
dc.identifier.issn0140-7783
dc.identifier.issn1365-2885
dc.identifier.pmid39279275
dc.identifier.scopus2-s2.0-85204065603
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/jvp.13481
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7153
dc.identifier.wosWOS:001313623300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectbioavailability
dc.subjectflunixin
dc.subjectpharmacokinetics
dc.subjectplasma protein binding
dc.subjectrainbow trout
dc.titlePharmacokinetics and Plasma Protein Binding of Flunixin in Rainbow Trout (Oncorhynchus mykiss)
dc.typeArticle

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