Nephroprotective effect of Ferulago angulata flowers on N-nitrosodimethylamine-induced nephrotoxicity in rats and its phytochemical profile

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dc.authoridGok, Hasya Nazli/0000-0003-4115-7509
dc.authoridEkin, Suat/0000-0002-6502-5028
dc.contributor.authorEkin, Suat
dc.contributor.authorKiziltas, Hatice
dc.contributor.authorAkkoyun, Mahire Bayramoglu
dc.contributor.authorEkin, Hasya Nazli
dc.contributor.authorYildirim, Serkan
dc.contributor.authorOto, Gokhan
dc.contributor.authorAkbas, Esvet
dc.date.accessioned2024-12-24T19:29:34Z
dc.date.available2024-12-24T19:29:34Z
dc.date.issued2019
dc.departmentSiirt Üniversitesi
dc.description.abstractThe present study was designed to assess the phytochemical content of Ferulago angulata (FA) and possible in vivo nephroprotective effect of FA administration on trace elements, minerals, MDA and GSH in kidney and liver tissue samples, serum vitamin (alpha-tocopherol, retinol, cholecalciferol, phylloquinone), TSA, and LSA in a rat model of DMN-induced nephrotoxicity. In the study, Wistar albino rats were assigned to six groups: Control (0.9% NaCl), (DMN 10 mg/kg), (FA 150 mg/kg), (DMN + FA 150 mg/kg), (FA 300 mg/kg), and (DMN + FA 300 mg/kg). Rats were intraperitoneally given DMN for the first 7 days. Renal injury caused by DMN was proved by the histopathological alterations. The FA (300 mg/kg) treatment significantly normalized Se, Cr, Ca levels in liver and Co level in kidney tissue samples. These observed positive effects are due to the phytochemical content of the plant. The flower extract of FA (300 mg/kg) can be used for the prevention of kidney damage. Practical applications Ferulago angulata flowers are used in traditional medicine for treat kidney and liver digestive system diseases. This species is endemic taxa of the family Apiaceae, which has been used both as food and therapeutics because of their phytochemical composition. In this study, the phenolic characterization of FA flower was used to a new RP-HPLC method, as well as the biological activity of FA flower and possible in vivo nephroprotective effect of FA flowers on trace elements, minerals, MDA and GSH in kidney and liver tissue samples and vitamins, TSA, and LSA in serum samples a rat model of DMN-induced nephrotoxicity. It was found that high level of phenolic compounds (chlorogenic acid, vanillic acid, 2-hydroxycinnamic acid) present in the flower extract of F. angulata has positive effects and antioxidant properties. Due to its phenolic content, FA flower extract could protect for kidney damage and can be used as antioxidants in the food additive and pharmaceutical industry.
dc.identifier.doi10.1111/jfbc.13030
dc.identifier.issn0145-8884
dc.identifier.issn1745-4514
dc.identifier.issue11
dc.identifier.pmid31482601
dc.identifier.scopus2-s2.0-85071778432
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/jfbc.13030
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7139
dc.identifier.volume43
dc.identifier.wosWOS:000493081400017
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Food Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectDMN
dc.subjectFerulago angulata
dc.subjectkidney
dc.subjectphenolics
dc.subjecttrace element
dc.subjectvitamin
dc.titleNephroprotective effect of Ferulago angulata flowers on N-nitrosodimethylamine-induced nephrotoxicity in rats and its phytochemical profile
dc.typeArticle

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