Investigation of the Protective Effect of Kefir against Isoproterenol Induced Myocardial Infarction in Rats

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dc.authoridYILDIRIM, Serkan/0000-0003-2457-3367
dc.contributor.authorMert, Handan
dc.contributor.authorYilmaz, Hikmet
dc.contributor.authorIrak, Kivanc
dc.contributor.authorYildirim, Serkan
dc.contributor.authorMert, Nihat
dc.date.accessioned2024-12-24T19:32:58Z
dc.date.available2024-12-24T19:32:58Z
dc.date.issued2018
dc.departmentSiirt Üniversitesi
dc.description.abstractThis study aims to investigate the protective effects of kefir against myocardial infarction induced by isoproterenol (ISO). The rats were randomly divided into 4 groups, each group consisting of 8 rats. The control group, the kefir group (5 mL/kg/d kefir administered to rats as intra-gastric gavage for 60 d), the ISO group (100 mg/kg ISO was administered to rats, s.c. on 61. and 62. d), and kefir+ISO group (5 mL/kg/d kefir was administered to rats intra gastric gavage for 60 days prior to ISO, 100 mg/kg in two doses on day 61 and 62). 12 h after the last ISO dose, all rats were decapitated and their blood samples were collected. Cardiac tissue was reserved for histopathological examination. creatine kinase (CK), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), triglycerides, total cholesterol,very low density lipoprotein (VLDL), low density lipoprotein (LDL), high density lipoprotein (HDL) and glucose were measured by autoanalyzer, whole blood malondialdehyde (MDA), glutathione (GSH) and plasma advanced oxidation protein products (AOPP) levels were measured spectrophotometrically. It was determined that in the group of kefir+ISO, the levels of AST (p<0.001), CK (p<0.001), LDH (p<0.001), MDA (p<0.001) and AOPP (p<0.001) were decreased, while the GSH (p<0.05) increased, compared to ISO group. There were no significant changes in lipid profile and glucose levels between these two groups. In conclusion, by examining cardiac enzymes and histopathological changes in cardiac tissue, it can be concluded that the administration of kefir in myocardial infarction induced by ISO can protect the heart with its antioxidant characteristic and minimize the toxic damage created by ISO.
dc.description.sponsorshipScientific Research Project Coordination Unit of Yuzuncu Yil University [2015-SBE-YL-248]
dc.description.sponsorshipThis work was supported by Scientific Research Project Coordination Unit of Yuzuncu Yil University as 2015-SBE-YL-248 project. This manuscript is summarized from master's thesis of Hikmet YILMAZ.
dc.identifier.doi10.5851/kosfa.2018.38.2.259
dc.identifier.endpage272
dc.identifier.issn1225-8563
dc.identifier.issue2
dc.identifier.pmid29805276
dc.identifier.scopus2-s2.0-85047094820
dc.identifier.scopusqualityN/A
dc.identifier.startpage259
dc.identifier.urihttps://doi.org/10.5851/kosfa.2018.38.2.259
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7903
dc.identifier.volume38
dc.identifier.wosWOS:000431741900005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKorean Soc Food Science Animal Resources
dc.relation.ispartofKorean Journal For Food Science of Animal Resources
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectantioxidant
dc.subjectcardiac marker
dc.subjectisoproterenol
dc.subjectkefir
dc.subjectmyocardial infarction
dc.titleInvestigation of the Protective Effect of Kefir against Isoproterenol Induced Myocardial Infarction in Rats
dc.typeArticle

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