Renoprotective effects of Silybum marianum (L.) Gaertn (Silymarin) on thioacetamide-induced renal injury: Biochemical and histopathological approach

Basit Öğe Kaydı
dc.authoridCENGIZ, Mustafa/0000-0002-6925-8371
dc.contributor.authorCengiz, Mustafa
dc.date.accessioned2024-12-24T19:33:06Z
dc.date.available2024-12-24T19:33:06Z
dc.date.issued2018
dc.departmentSiirt Üniversitesi
dc.description.abstractThioacetamide (TAA), recognized as an experimental toxin, mainly causes acute liver damage through the production of free radicals. TAA as well induces renal dysfunction hence; renal failure is often related with the end-stage of the hepatic damage. The aim of the current study was to examine the protective effects of Silymarin (Sil) against TAA-induced kidney damage in this current study. The twenty eight rats were separated into four groups. Group I was performed as control (saline 0,5 mL intraperitonally i.p.). Group 2 was given to 50 mg/kg TAA (i.p.). Group 3 was administrated with TAA just after 50 mg/kg Sil (per os (p.o.)). Group 4 was treated to TAA just after 100 mg/kg Sil. In end (fourteenth days) of study, tissue and blood samples of animals were collected for morphological and biochemical assessment. Our results show that Sil treatment apart from the TAA administration profitably changed the poisonous effects on the rats. In addition, 100 mg/kg Sil was more protective than 50 mg/kg Sil treatment indicated by histopathological, and biochemical values. In conclusion, Sil therapy before TAA could guard kidney tissues against TAA induced nephrotoxicity.
dc.identifier.endpage2141
dc.identifier.issn1011-601X
dc.identifier.issue5
dc.identifier.pmid30393224
dc.identifier.scopus2-s2.0-85056287998
dc.identifier.scopusqualityQ3
dc.identifier.startpage2137
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7950
dc.identifier.volume31
dc.identifier.wosWOS:000447576200017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherUniv Karachi
dc.relation.ispartofPakistan Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectSilymarin
dc.subjectrenoprotectivity
dc.subjectthioacetamide
dc.subjectnephrotoxicity
dc.titleRenoprotective effects of Silybum marianum (L.) Gaertn (Silymarin) on thioacetamide-induced renal injury: Biochemical and histopathological approach
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu