The protective effect of arbutin against potassium bromate-induced oxidative damage in the rat brain

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dc.authoridEkin, Suat/0000-0002-6502-5028
dc.authoridbengu, aydin sukru/0000-0002-7635-4855
dc.authoridKARAGOZOGLU, FATMA/0000-0001-7970-0306
dc.authoridAydin, Sevinc/0000-0001-8597-8064
dc.contributor.authorAkkoyun, H. Turan
dc.contributor.authorUyar, Ahmet
dc.contributor.authorAkkoyun, Mahire Bayramoglu
dc.contributor.authorBengu, Aydin Sukru
dc.contributor.authorMelek, Sule
dc.contributor.authorKaragozoglu, Fatma
dc.contributor.authorAydin, Sevinc
dc.date.accessioned2024-12-24T19:24:11Z
dc.date.available2024-12-24T19:24:11Z
dc.date.issued2023
dc.departmentSiirt Üniversitesi
dc.description.abstractThis study aimed to investigate the protective effects of arbutin (ARB) against brain injury induced in rats with potassium bromate (KBrO3). The rats were divided into four groups as Group 1: Control (0.9% NaCl ml/kg/day p.), Group 2: KBrO3 (100 mg/kg (gavage), Group 3: ARB (50 mg/kg/day p.), and Group 4: KBrO3 + ARB (100 mg/kg (gavage) + 50 mg/kg/day p.). At the end of the fifth day of the study, the rats in all groups were killed, and their brain tissues were collected. In the collected brain tissues, malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) levels were measured, and routine histopathological examinations were made. The MDA levels in the group that was exposed to KBrO3 were significantly higher than those in the control group (p < 0.001). In comparison to the KBrO3 group, the MDA levels in the KBrO3 + ARB group were significantly lower (p < 0.001). It was observed that SOD and CAT enzyme activity levels were significantly lower in the KBrO3 group compared to the control group (p < 0.001), while these levels were significantly higher in the KBrO3 + ARB group than in the KBrO3 group (p < 0.001). Additionally, the group that was subjected to KBrO3 toxicity, as well as ARB administration, had much lower levels of histopathologic signs than the group that was subjected to KBrO3 toxicity only. Consequently, it was found that KBrO3 exposure led to injury in the brain tissues of the rats, and using ARB was effective in preventing this injury.
dc.identifier.doi10.1002/jbt.23248
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue2
dc.identifier.pmid36284482
dc.identifier.scopus2-s2.0-85140376366
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/jbt.23248
dc.identifier.urihttps://hdl.handle.net/20.500.12604/5886
dc.identifier.volume37
dc.identifier.wosWOS:000871772200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Biochemical and Molecular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectarbutin (beta-d-glucopyranoside
dc.subject4-hydroxyphenyl)
dc.subjectcatalase (CAT)
dc.subjectmalondialdehyde (MDA)
dc.subjectpotassium bromate (KBrO3)
dc.subjectsuperoxide dismutase (SOD)
dc.titleThe protective effect of arbutin against potassium bromate-induced oxidative damage in the rat brain
dc.typeArticle

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