Comparison of orexigenic and anorexigenic neuropeptide levels in hyperemesis gravidarum patients with normal pregnant women: A prospective cohort study

Basit Öğe Kaydı
dc.authoridAKSIN, SERIF/0000-0002-1301-2508
dc.authoridyilmaz, mehmet/0000-0002-9930-4156
dc.contributor.authorYilmaz, Mehmet
dc.contributor.authorAksin, Serif
dc.contributor.authorBalsak, Deniz
dc.contributor.authorAboalhasan, Yasmin
dc.contributor.authorBatmaz, Ibrahim
dc.date.accessioned2024-12-24T19:28:30Z
dc.date.available2024-12-24T19:28:30Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractBackground: The aim of this study was to determine whether orexigenic neuropeptides, orexin and galanin, and anorexigenic neuropeptides, alpha-melanocyte-stimulating hormone (alpha-MSH) and cocaine- and amphetamine-regulated transcript (CART), are implicated in hyperemesis gravidarum (HG). Methods: Fifty pregnant women who had been diagnosed with HG between April 2022 and February 2023 at the Siirt University Faculty of Medicine Training and Research Hospital (tertiary center) were recruited for this study. An equal number of pregnant women without an HG diagnosis were included in the study as the control group. Participants' age, pregnancy history, medical history, thyroid function test results, complete blood count results, and electrolyte levels were recorded, and their orexin, galanin, alpha-MSH, and CART serum levels were analyzed using an enzyme-linked immunosorbent assay. Results: No statistically significant differences in orexigenic neuropeptides (orexin and galanin) were observed between the HG and control groups. A statistical difference was found between an anorexigenic neuropeptide (alpha-MSH) and the control group (P = .012). Based on a receiver operating characteristic analysis, the alpha-MSH parameter was statistically significant for distinguishing between participants with an HG diagnosis and those without, with a sensitivity of 63.6%, specificity of 65.9%, and cutoff value of 11769.3 pg/mL (P = .012, area under curve: 0.655). Based on the severity classification of ketonuria (ketonuria levels of +1 or +2 were classified as mild, whereas levels of +3 or +4 were classified as moderate to severe), the anorexigenic CART neuropeptide was found to be a statistically significant diagnostic indicator of severe ketonuria (P = .020). Conclusion: alpha-MSH and CART levels were found to be related in HG patients and in HG patients with severe ketonuria.
dc.description.sponsorshipSiirt University Scientific Research Project Directorate [2022-SIUTIP-054]
dc.description.sponsorshipWe would like to thank the Siirt University Scientific Research Project Directorate for its contributions to this research (Project number: 2022-SIUTIP-054).
dc.identifier.doi10.1097/MD.0000000000040069
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.issue42
dc.identifier.pmid39432622
dc.identifier.scopus2-s2.0-85206961824
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1097/MD.0000000000040069
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7093
dc.identifier.volume103
dc.identifier.wosWOS:001358481200009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofMedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectCART
dc.subjectgalanin
dc.subjecthyperemesis gravidarum
dc.subjectorexin
dc.subjectalpha-MSH
dc.titleComparison of orexigenic and anorexigenic neuropeptide levels in hyperemesis gravidarum patients with normal pregnant women: A prospective cohort study
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu