Neuroprotective effects of the combined treatment of resveratrol and urapidil in experimental cerebral ischemia-reperfusion injury in rats

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dc.authoridKaya, Seval/0000-0001-6251-6529
dc.authoridBAHADIR, Sinan/0000-0002-1037-5645
dc.authoridCETIN, RIDVAN/0000-0002-0196-7198
dc.authoridGuzel, Baris Can/0000-0002-2504-120X
dc.contributor.authorCetin, Ridvan
dc.contributor.authorBahadir, Sinan
dc.contributor.authorBasar, Ibrahim
dc.contributor.authorAslanoglu, Baris
dc.contributor.authorAtlas, Burak
dc.contributor.authorKaya, Seval
dc.contributor.authorGuzel, Baris Can
dc.date.accessioned2024-12-24T19:30:20Z
dc.date.available2024-12-24T19:30:20Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractPurpose: To evaluate the neuroprotective effect of resveratrol, urapidil, and a combined administration of these drugs against middle cerebral artery occlusion (MCAO) induced ischemia/reperfusion (IR) injury model in rats. Methods: Thirty-five rats were divided into five groups of seven animals each. Animals in IR, IR resveratrol (IRr), IR urapidil (IRu), and IR + combination of resveratrol and urapidil (IRc) were exposed to MCAO induced cerebral ischemia reperfusion injury model. Rats in IRr and IRu groups received 30-mg/kg resveratrol and 5-mg/kg urapidil respectively. Animals in IRc received a combined treatment of both drugs. At the end of the study, brain tissues were used for oxidative stress (malondialdehyde, glutathione, and superoxide dismutase), pro-apoptotic caspase-3, anti-apoptotic Bcl-2, and pro-inflammatory tumor necrosis factor-alpha cytokine level measurements. Results: The MCAO model successfully replicated IR injury with significant histopathological changes, elevated tissue oxidative stress, and upregulated apoptotic and inflammatory protein expression in IR group compared to control group (p < 0.001). All parameters were significantly alleviated in IRr group compared to IR group (all p < 0.05). In IRu group, all parameters except for caspase-3 and Bcl-2 were also significantly different than IR group (all p < 0.05). The IRc group showed the biggest difference compared to IR group in all parameters (all p < 0.001). The IRc had higher superoxide dismutase and Bcl-2 levels, and lower caspase-3 levels compared to both IRr and IRu groups (all p < 0.05). Also, the IRc group had lower MDA and TNF-alpha levels compared to IRu group (all p < 0.05). Conclusion: The results indicate that combined treatment of resveratrol and urapidil may be a novel strategy to downregulate neurodegeneration in cerebral IR injury.
dc.identifier.doi10.1590/acb395329
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.pmid39109783
dc.identifier.scopus2-s2.0-85200828377
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1590/acb395329
dc.identifier.urihttps://hdl.handle.net/20.500.12604/7490
dc.identifier.volume39
dc.identifier.wosWOS:001286262800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectBrain Ischemia
dc.subjectResveratrol
dc.subjectUrapidil
dc.subjectOxidative Stress
dc.subjectApoptosis
dc.subjectRats
dc.titleNeuroprotective effects of the combined treatment of resveratrol and urapidil in experimental cerebral ischemia-reperfusion injury in rats
dc.typeArticle

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