Synthesis and biological evaluation of quinoline-triazole and quinolone-triazole conjugates

Basit Öğe Kaydı
dc.authoridOkumus, Veysi/0000-0002-5505-2700
dc.authoridGumus, Aysegul/0000-0002-1613-7074
dc.contributor.authorGumus, Aysegul
dc.contributor.authorOkumus, Veysi
dc.date.accessioned2024-12-24T19:33:57Z
dc.date.available2024-12-24T19:33:57Z
dc.date.issued2018
dc.departmentSiirt Üniversitesi
dc.description.abstractOne-pot synthesis of novel quinoline- and quinolone-substituted 1,2,3-triazoles has been performed from the key intermediates, quinoline- and quinolone-substituted propargyl derivatives 1-3 (48%-88% yields). The antioxidant properties of the newly synthesized compounds, 1a-1c, 2a-2c, and 3a-3c, were evaluated by monitoring DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging abilities, metal chelating effects, and reducing power. The scavenging effects of compounds on the free radical decreased in the order of 3b > 3a > 1b and were found to be 36.3%, 34.9%, and 27.6% at the concentration of 500 mu g/mL, respectively. All of the compounds showed low chelating capacity. Furthermore, the antibacterial activity was studied against gram-positive and gram-negative bacteria and the DNA binding ability of the compounds was evaluated with calf thymus DNA using agarose gel electrophoresis.
dc.identifier.doi10.3906/kim-1804-18
dc.identifier.endpage1357
dc.identifier.issn1300-0527
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85054924363
dc.identifier.scopusqualityQ3
dc.identifier.startpage1344
dc.identifier.trdizinid381672
dc.identifier.urihttps://doi.org/10.3906/kim-1804-18
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/381672
dc.identifier.urihttps://hdl.handle.net/20.500.12604/8346
dc.identifier.volume42
dc.identifier.wosWOS:000451313100013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241222
dc.subjectQuinoline
dc.subjectquinolone
dc.subjecttriazole
dc.subjectantioxidant
dc.subjectantibacterial
dc.titleSynthesis and biological evaluation of quinoline-triazole and quinolone-triazole conjugates
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu