Carbapenem-resistant Klebsiella pneumoniae strains isolated from clinical specimens in Siirt, Türkiye; molecular characterization and antimicrobial resistance genes detection

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dc.contributor.authorGunes, Sevgi
dc.contributor.authorAcer, Omer
dc.contributor.authorBahce, Yasemin Genc
dc.date.accessioned2024-12-24T19:27:00Z
dc.date.available2024-12-24T19:27:00Z
dc.date.issued2024
dc.departmentSiirt Üniversitesi
dc.description.abstractThis study aimed to molecularly identify carbapenem-resistant Klebsiella pneumoniae (CRKP) strains isolated from clinical samples and to determine antibiotic resistance genes. Only carbapenem-resistant strains were included in our study. Of the 35 CRKP strains, 18 (51.4%) were extensive drug, 11 (31.4%) were multi-drug, and 6 (17.1%) were pan-drug resistances. PCR amplification revealed that 25% of the strains carried the OXA-51, 20% the OXA48, and %5 the OXA23 genes. Multilocus sequence typing (MLST) analysis based on seven house-keeping genes revealed sequence type 39. The capsule and O-antigen types were determined as KL103 and O2a, respectively. WGS analysis revealed the existence of (3-lactamase, aminoglycoside, sulfonamide, Phenicol, and Fosfomycinresistant genes. While the K. pneumoniae OmpK37 gene was detected in all 3 strains, the OmpK36 gene was detected only in the CRSU20 strain. This study is important as it is the first study to perform molecular analysis of CRKP strains from Siirt, T & uuml;rkiye.
dc.identifier.doi10.1016/j.diagmicrobio.2024.116414
dc.identifier.issn0732-8893
dc.identifier.issn1879-0070
dc.identifier.issue2
dc.identifier.pmid39032321
dc.identifier.scopus2-s2.0-85198954405
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.diagmicrobio.2024.116414
dc.identifier.urihttps://hdl.handle.net/20.500.12604/6458
dc.identifier.volume110
dc.identifier.wosWOS:001275784800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241222
dc.subjectAntibiotic resistance genes
dc.subjectCarbapenem-resistance K. pneumoniae
dc.subjectWhole genome sequencing
dc.titleCarbapenem-resistant Klebsiella pneumoniae strains isolated from clinical specimens in Siirt, Türkiye; molecular characterization and antimicrobial resistance genes detection
dc.typeArticle

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